NEW BRUNSWICK, N.J. (PRWEB) March 26, 2018
Natreon, a nutritional ingredient company, was granted a US Patent (US 9,901,596) on 3-hydroxy-dibenzo-α-pyrone (3-OH-DBP), also known as Urolithin B, a natural bioactive present in shilajit, for prevention and/or treatment of body weight gain. International patents are pending.
Natreon was also issued a US patent (US 8,894,993) in 2014 on a combination of 3,8-dihydroxy-dibenzo-α-pyrone (3,8-(OH)2-DBP), also known as Urolithin A, or 3-OH-DBP (Urolithin B) and CoQ10/Ubiquinol, as mitochondria-targeted antioxidants for treatment of mitochondrial disorders.
Both DBPs (urolithins) are bioactive components of shilajit, and the fulvic acids in shilajit have the core nucleus made up of DBPs. Shilajit is a mineral-rich substance found in Himalayan and Altai mountain areas and used in Ayurvedic medicine. Shilajit is also known as “moomiyo” in Russia. DBPs are present in shilajit in free form as well as in conjugation with chromoproteins.
There has been a significant amount of research conducted on urolithins recently. One of the most recent theories prevailing is that the ellagitannins from the diet, especially fruits such as pomegranate, are converted to urolithins by the microbiome in the GI tract, which are then absorbed into the blood stream, providing immunity. Natreon’s research at Ohio State University Wexner Medical Center has shown that DBPs are present in animal tissue and have significant mitochondrial activity. Natreon is planning clinical studies on these compounds.
Natreon’s scientific research includes process optimization, development of chromatographic analytical methods such as HPLC, HPTLC, GC-MS and LC-MS-MS for standardization, development of marker compounds, and pharmacological studies. Its R&D team is headed by Prof. Shibnath Ghosal, a Fulbright scholar and an eminent natural product chemist with hundreds of publications in scientific journals and a group of Ph.D. and master’s degree level scientists.
For more information on Natreon and its research and development, visit its website at https://natreoninc.com/.
About Natreon, Inc.:
Since 1998, New Jersey-based company Natreon Inc. has been scientifically studying and testing Ayurvedic ingredients to introduce to food and beverage, dietary supplement, medical food and personal care industries. With a state-of-the-art R&D facility in Kolkata, India, Natreon is focused on developing and marketing Ayurvedic products backed by extensive research, a high degree of standardization, clinical and safety studies, and intellectual property. Its safety studies are carried out in the USA, and its clinical studies are conducted in both the USA and reputed institutes in India.
Natreon, Inc. Key Executives:
Dr. Sanni Raju – CEO/Chairman
Bruce Brown - President