Dallas, TX (PRWEB) July 16, 2014
The amyotrophic lateral sclerosis (ALS) treatment market value will decline from $64 million in 2013 to $38 million by 2018, at a negative Compound Annual Growth Rate (CAGR) of 10.05%, according to research and consulting firm. The company’s latest report “OpportunityAnalyzer: Amyotrophic Lateral Sclerosis (ALS) - Opportunity Analysis and Forecasts to 2018” states that the largest factor in this decline, which will occur over seven major markets (7MM: the US, France, Germany, Italy, Spain, the UK, and Japan), will be the patent expiration of Rilutek (riluzole), the only approved therapy for ALS.
As a consequence, Researcher forecasts that the ALS treatment market in the US is set to suffer a substantial reduction in sales over the forecast period, from $38 million in 2013 to $16 million by 2020, at a negative CAGR of 16.10%. The effect of Rilutek’s patent expiration will be exacerbated by the lack of alternative treatments in the ALS pipeline. Additionally, the recent failure of several previously promising Phase III pipeline compounds has restricted the growth of an interest in the amyotrophic lateral sclerosis therapeutics market.
The analyst believes that there is a drastic need for new therapies that can alleviate the symptoms of the disease and stop or reverse its pathology. The unmet needs in amyotrophic lateral sclerosis are reflected in the limited diversity of the current pipeline, but no dominant theories have emerged to help guide drug development. There are two pipeline drugs that will supplement Rilutek and off-label therapies. AB Science’s AB-1010, an oral tyrosine kinase inhibitor, targets the inflammatory processes that are believed to contribute to the pathogenesis of ALS, while Cytokinetics’ tirasemtiv aims to improve muscle strength through fast-muscle troponin activation. While these medications will provide greater relief of symptoms, they will not be able to reverse the course of the disease, the analyst concludes.
Key Questions Answered
This report provides an overview of amyotrophic lateral sclerosis (ALS), including etiology and pathophysiology, general symptoms, quality of life, country-specific treatment recommendations and epidemiologic data. It also covers annualized amyotrophic lateral sclerosis market, treatment and usage patterns from 2013 to 2018. Key topics covered include unmet needs analysis, research and development strategies, pipeline assessment and pipeline valuation analysis.
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