These specimens provide the opportunity to screen for novel biomarker expressions including the expression patterns of the programmed cell death protein-1/ programmed cell death ligand-1 (PD1/PDL1) pathway.
TORONTO (PRWEB) October 24, 2022
The acquisition of fresh human tissue is often an impediment to significant research advances. As an alternative, Discovery Life Sciences offers cryopreserved human dissociated tumor cells (DTCs) and tissues as a viable specimen source for many downstream applications, including immunophenotyping, bulk and single-cell sequencing, and single-cell functionality. Extensive cellular profiling of DTCs by flow cytometry revealed indication-specific trends in the composition of the tumor microenvironment. Additionally, these specimens provide the opportunity to screen for novel biomarker expressions including the expression patterns of the programmed cell death protein-1/ programmed cell death ligand-1 (PD1/PDL1) pathway.
Workflow optimizations and the integration of a large DTCs biobank with a full scale cell services laboratory provide improved assay performance and shortened study timelines. Finally, as viable cell suspensions, dissociated human tissues can be utilized in both short-term and long-term cultures, and the functionality of tumor-infiltrating T cells can be evaluated using IsoPlexis single-cell proteomic pipelines. Collectively, cryopreserved dissociated human tissue combined with cellular and proteomic services allow for a multifaceted analysis of the next generation of cancer therapies.
Register to learn about the applications of cryopreserved human dissociated tumor cells (DTCs) for drug and diagnostic development.
Join Shawn Fahl, PhD, VP Lab Operations, Cell Services & R&D, Biospecimens, Discovery Life Sciences, for the live webinar on Monday, November 7, 2022, at 9am EST (3pm CET/EU-Central).
For more information, or to register for this event, visit Applications of Cryopreserved Human Dissociated Tumor Cells (DTCs) for Drug and Diagnostic Development.
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