Dallas, TX (PRWEB) July 20, 2014
Neuropathic pain (NP) is defined as a disorder of the sensorimotor system and is distinctly different from nociceptive pain, which is a consequence of trauma, injury, or inflammation. The main difference between neuropathic and nociceptive pain is the absence of a continuous nociceptive input in neuropathic pain. Although the term neuropathic pain is used to describe a wide range of pain syndromes with varying etiologies, this report focuses on 3 distinct forms of NP: Painful diabetic neuropathy, Postherpetic neuralgia and trigeminal neuralgia.
The main classes of drugs used to treat these three neuropathic pain indications include anticonvulsants, antidepressants, opioids and topical treatments. However, despite the availability of multiple pain medications only 50% of patients respond to any given drug and there are numerous the side effects associated particularly with systemically administered drugs, that reduce their tolerability. New treatments will target some key unmet needs in terms of efficacy and tolerability, but opportunities will remain for drugs that can more reliably eradicated NP in targeted patient populations, as well as offering an improved safety profile.
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Cebranopadol (GRT-6005) is a small-molecule opioid analgesic that is being developed by Grünenthal for the treatment of moderate to severe chronic pain conditions. In December 2010, Grünenthal entered into a licensing agreement with Forest Laboratories for the co-development and commercialization of cebranopadol and its follow-on compound, GRT-6006. The drug is currently in Phase IIb of clinical development for PDN, and is also in Phase III of development for cancer pain, as well as in Phase II for chronic nociceptive pain, moderate to severe pain due to osteoarthritis of the knee, and chronic low back pain.
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Table of Contents
1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2.2 Related Reports
3 Disease Overview
3.1 Clinical Manifestations of Neuropathic Pain - Signs and Symptoms
3.1.1 Painful Diabetic Neuropathy
3.1.2 Postherpetic Neuralgia
3.1.3 Trigeminal Neuralgia
3.2 Etiology and Pathophysiology
4 Disease Management
4.1 Diagnosis and Treatment Overview
4.1.2 Treatment Overview and Guidelines
5 Competitive Assessment
6 Unmet Need and Opportunity
6.2 Physician Knowledge or Awareness
6.2.1 Unmet Need
6.2.2 Gap Analysis
6.3 Diagnostic Challenges
6.3.1 Unmet Need
6.3.2 Gap Analysis
6.4 Low Treatment Rate and Underdosing of Medications
6.4.1 Unmet Need
6.4.2 Gap Analysis
6.5 Unsatisfactory Efficacy and Safety Profiles of Pharmacological Treatments
6.5.1 Unmet Need
6.5.2 Gap Analysis
6.6 Elderly Patient Population - Drug Tolerability
6.6.1 Unmet Need
6.6.2 Gap Analysis
6.7 Rational or Personalized Therapies
6.7.1 Unmet Need
6.7.2 Gap Analysis
7 Pipeline Assessment
7.2 Promising Drugs in Clinical Development
8.4 Dosing and Formulation
8.5 Potential Clinical and Commercial Positioning
8.6 Pricing and Reimbursement
8.7 SWOT Analysis
9.4 Forecasting Methodology
9.4.1 Diagnosed PDN, PHN, and TN Patients
9.4.2 Percent Drug-Treated Patients
9.4.3 General Pricing Assumptions
9.4.4 Generic Erosion
9.4.5 Pricing of Pipeline Agents
9.5 Physicians and Specialists Included in This Study
9.6 About the Authors
9.6.2 Global Head of Healthcare
9.7 About GlobalData
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