Clinical Study Results Show DuPont Probiotics Reduce Risk of Respiratory Symptoms in Healthy Adults

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Clinical Nutrition Publishes New Study that Demonstrates the Immune Health Benefits of HOWARU® Protect

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These results reinforce our existing documentation on probiotic solutions for immune health and open new opportunities for the HOWARU® Protect range.

DuPont Nutrition & Health welcomes new clinical evidence on the impact of DuPont™ Danisco® HOWARU® Protect probiotics in helping to maintain respiratory health for healthy adults. Investigated in a joint clinical study by Australian research institutes, two probiotic formulations were seen to reduce the risk of and delay the onset of respiratory illness, and to improve training load during physical exercise.

The study titled, “Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals,” was just published in Clinical Nutrition, the official journal of the European Society for Clinical Nutrition and Metabolism. It is available online at: (publication), (article).

Gold Standard Trial

Scientists from Griffith University conducted the randomized, double-blind, placebo controlled clinical trial in cooperation with the Australian Institute of Sport and other collaborating institutions. The 465 trial subjects were split into three groups, each receiving a daily dose of HOWARU® Protect Adult, HOWARU® Protect Sport or a placebo. All subjects were healthy adults who exercised for at least 30 minutes, three times per week.

Risk of Cold-Like Symptoms Reduced 27 Percent

Daily supplementation with Bifidobacterium animalis subsp. lactis Bl-04TM – known commercially as HOWARU® Protect Adult – produced the most notable result. In the healthy men and women who consumed a daily dose over the five-month study period, the risk of upper respiratory tract illness (URTI) was reduced by 27 percent.

The results also indicate that Bl-04™ supports respiratory health, with trial subjects remaining free of upper respiratory symptoms for several weeks longer, on average, than those in the placebo group.

“A significant delay in the onset of symptoms indicates that this probiotic strain may help active adults stay healthy longer,” said Professor Allan Cripps, pro-vice chancellor, Health at Griffith University and the principal scientist of the study.

Increased Physical Activity

A tendency toward reduced respiratory illness episodes and significant delay in the onset of symptoms also was observed among subjects who received the other probiotic formulation – Bifidobacterium animalis subsp. lactis Bi-07TM and Lactobacillus acidophilus NCFM®, available from DuPont as HOWARU® Protect Sport. The most notable finding in this group, however, was a significantly higher level of physical activity, possibly due to the delayed time to symptoms.

“It is a known fact that physical activity is reduced or may even stop when people are feeling the effects of respiratory symptoms. So, these findings are important, particularly for those who engage in competitive sports and need to maintain fitness,” said Professor David Pyne, senior physiologist at the Australian Institute of Sport and lead investigator of the study.

“These results reinforce our existing documentation on probiotic solutions for immune health and open new opportunities for the HOWARU® Protect range,” said Didier Carcano, health platform leader, DuPont Nutrition & Health.

DuPont™ Danisco® is the brand for a range of ingredients that help provide enhanced bioprotection, an improved nutritional profile, and better taste and texture with greater cost efficiency and lower environmental impact, meeting the needs of manufacturers of food and beverages, dietary supplements and pet food. Through the work of the global network of food scientists and technologists in DuPont, the Danisco® range is supported by a uniquely broad spectrum of know-how across applications and processing. For more information on DuPont™ Danisco®, go to:

DuPont Nutrition & Health addresses the world’s challenges in food by offering a wide range of sustainable, bio-based ingredients and advanced microbial diagnostic solutions to provide safer, healthier and more nutritious food. Through close collaboration with customers, DuPont combines knowledge and experience with a passion for innovation to deliver unparalleled customer value to the marketplace.

DuPont (NYSE: DD) has been bringing world-class science and engineering to the global marketplace in the form of innovative products, materials, and services since 1802. The company believes that by collaborating with customers, governments, NGOs, and thought leaders we can help find solutions to such global challenges as providing enough healthy food for people everywhere, decreasing dependence on fossil fuels, and protecting life and the environment. For additional information about DuPont and its commitment to inclusive innovation, please visit

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Sarah-Jane Jumppanen
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