an appropriately detailed assessment of the host response will substantially inform the evaluation of antimicrobial prophylactics and therapeutics.
TORONTO (PRWEB) June 10, 2020
Understanding both pathogen and host, and their interactions, is essential to fully assess the effect of infectious diseases. The gold standard for diagnosis of an infection has been to demonstrate the presence of pathogen. However, disease severity, progression and the response to treatment are often more dependent on the status of the host. Therefore, an appropriately detailed assessment of the host response will substantially inform the evaluation of antimicrobial prophylactics and therapeutics.
The immune response is complex and collaborative. A robust immune response requires multiple cell lineages and soluble factors to work in concert. It is also influenced by multiple host factors including co-morbidities, levels of immune competence, type of response and age of the host. These factors are often meaningfully associated with specific at-risk populations and therefore need to be accounted for in development programs. All of these are risk factors associated with COVID-19 disease severity in high-risk groups. Age and immune function have also been shown to affect vaccination in general. Furthermore, the immune correlates of protection necessary for successful vaccine development may not be the same as those required for successful therapy development. A multi-disciplinary systems approach for the measurement of the host response is therefore required to successfully address all of these variables.
This presentation will support this argument by drawing examples from our extensive previous experience identifying infectious disease biomarkers in pre-clinical and clinical trial settings for diagnostic, disease progression or treatment response applications using a variety of platforms. The case studies will survey identification of predictive biomarkers of disease progression and response to vaccination, as well as cellular and soluble protein correlates of the vaccine response.
For more information or to register for this event, visit Multi-disciplinary Measurement of Host Biomarkers and Correlates in Infection and Immunity.
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