State College, PA (PRWEB) September 05, 2013
Salimetrics has completed the development of a new, fully validated assay kit for the measurement of interleukin-6 (IL-6) in saliva samples. The Salimetrics IL-6 assay is the only assay designed and validated specifically for the accurate measurement of IL-6 in saliva. Salimetrics is leading the cutting-edge of salivary research by providing premium assays for inflammatory and immune related markers, which researchers can add to their studies alongside the well-respected assays for stress hormones, sex hormones, and autonomic markers that researchers trust to deliver precise and consistent results.
In addition to the IL-6 assay, Salimetrics offers additional salivary immunoassay kits related to inflammation and immunity: IL-1 Beta, C-reactive protein, and secretory IgA. Salivary inflammatory markers for TNF-Alpha are currently available through The Salimetrics Laboratory, while a commercially available immunoassay is currently under development.
IL-6 is a key inflammatory signaling molecule released after infection, injury, or antigenic challenge, and is widely used as a biomarker of systemic inflammation. Circulating IL-6 is primarily released from immune cells, but it is also secreted from a wide variety of other tissues. IL-6 is also present in saliva due to production by immune cells, various oral tissues, and cells in the saliva glands.
The latest research suggests that salivary levels of interleukin-6 and other cytokines respond to psychological stress or antigenic challenges outside the oral cavity in a fashion similar to that seen in circulation. This research advises that circulating and oral levels of these markers may be influenced by similar autonomic signaling pathways. The relevance of IL-6 in saliva and GCF (gingival crevicular fluid) to the etiology of periodontitis or other oral diseases is well established in the literature, while further studies are required to explore the relationships of IL-6 and other cytokines in saliva to systemic inflammation and diseases outside the mouth. IL-6 signaling also contributes to periodontal disease pathology as a mediator of bone resorption by directly stimulating osteoclast differentiation.
Researchers interested in learning more about the Salimetrics salivary IL-6 immunoassay kit or incorporating IL-6 into their research project can find support through the Salimetrics website or by e-mailing support(at)salimetrics(dot)com.
Founded in 1998, Salimetrics, LLC supports researchers, the immunodiagnostic industry, and functional testing laboratories around the world with innovative salivary immunoassay products and services. Salimetrics’ assay kits and CLIA-certified testing services measure biomarkers related to stress, behavior and development, inflammation, and immune function, including: alpha-amylase, androstenedione, blood contamination, chromogranin A, cortisol, cotinine, C-reactive protein, DHEA, DHEA-S, estradiol, estriol, estrone, IL-1b, IL-6, melatonin, progesterone, 17α-hydroxyprogesterone, secretory IgA, testosterone, and TNF-a. Salimetrics also provides salivary DNA analysis. The company is based in State College, Pennsylvania, with offices in the UK and distributors around the world. For more information, visit Salimetrics on the web at http://www.salimetrics.com.