Salimetrics Cortisol Assay exhibits the best linearity and comes closest to the results found in tandem mass spectrometry.
(PRWEB) September 30, 2013
German scientists were seeking to compare studies that used different assays. In their study, published in the January 2013 issue of Psychoneuroendocrinology, they concluded that among commercially available assays, the Salimetrics assay for cortisol exhibits the best linearity and comes closest to the results found in tandem mass spectrometry. They confirmed that the different cortisol assays of Salimetrics, IBL, DRG, DSL and DELFIA produced results which could not be easily compared.
The scientists further suggest the inclusion of nonlinear model components to compensate for the “accuracy decrease towards lower cortisol values” which “is assumed to reflect the impact of cross-reactive saliva matrix antigens, mostly cortisone.”
“Of all the commercially available immunoassays, Salimetrics has the least cross reactivity with cortisone and therefore the Salimetrics product is the most accurate,” Salimetrics Principal Scientist Jon Peterson, Ph.D., explained. He added that “it is the mission of Salimetrics to provide immunoassays that are the standard for saliva-based biomarker research.”
The vast majority of salivary cortisol measurements are determined using immunoassays, the study’s authors, Robert Miller, Franziska Plessow, Manfred Rauh, Michael Groschl and Clemens Kirschbaum, noted. “Due to its non-invasiveness, precision and cost efficiency, the measurement of steroid levels from saliva has become a valuable tool in psychoneuroendocrinological research over the past two decades.” The scientists created models to compare the accuracies of different assay products to liquid chromatography coupled with tandem mass spectroscopy (LC-MS/MS) control results. These models showed that the Salimetrics assay had the lowest interference among the five immunoassays compared.
Salimetrics produces more than 23 biomarkers reliably measured in saliva and has the most comprehensive catalogue of commercially available salivary measures and tools provided by one source. There are distributors available worldwide. Hans Schroeder, Salimetrics CEO, notes that “although the science is complex, the driving force behind Salimetrics is simple: Better Collection. Better Assays. Better Results. Better Science.”
About Salimetrics: Founded in 1998, Salimetrics, LLC supports researchers, the immunodiagnostic industry and functional testing laboratories around the world with innovative salivary immunoassay products and services. Salimetrics’ collection techniques, assay kits and CLIA-certified testing services are used to measure biomarkers related to stress, behavior and development, inflammation, sleep, reproduction, health and immune function, including: alpha-amylase, androstenedione, blood contamination, chromogranin A, cortisol, cotinine, C-reactive protein, DHEA, DHEA-S, estradiol, estriol, estrone, IL-1b, IL-6, melatonin, NGF, progesterone, 17α-hydroxyprogesterone, secretory IgA, testosterone, and TNF-a. Salimetrics also provides salivary DNA analysis. The company is based in State College, Pennsylvania, with offices in the UK and distributors around the world. For more information, visit Salimetrics on the web at http://www.salimetrics.com.