Researchers Say New Biomarkers Could Improve Bladder Cancer Diagnosis and Treatment, According to Cancer Monthly

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Biochemical testing suggests a pair of proteins can find and monitor bladder cancer better than standard techniques.

Biomarkers for Bladder Cancer

Combined use of the cytology with the studied biomarkers can improve the sensitivity for detecting bladder cancer...

A team of Egyptian biochemists say angiogenin and clusterin – two proteins vital to certain cellular processes – could make bladder cancer diagnosis more accurate and treatments more effective. Click here to read details on the study which has just been posted on the Cancer Monthly website.

Researchers with the Faculty of Pharmaceutical Sciences and Pharmaceutical Technologies at Future University in Cairo evaluated the merits of testing for angiogenin and clusterin in the urine, along with standard urine cytology. Currently, cytology (looking for cancer cells in urine) and cystoscopy (examination of the bladder with a camera) are the primary tools used to detect suspected bladder cancer.

“Combined use of the cytology with the studied biomarkers can improve the sensitivity for detecting bladder cancer, and may be very useful in monitoring the effectiveness of antiangiogenic and apoptotic therapies in bladder cancer,” says researcher Marwa Shabayek, lead author of the study.

The study published in Pathology and Oncology Research involved 50 patients with malignant bladder cancer, 20 with benign bladder tumors, and 20 healthy subjects.

“It stands to reason that a test that improves the diagnosis of bladder cancer has the potential to also improve survival,” says Cancer Monthly’s Managing Editor Alex Strauss. “This is especially encouraging news for diabetics, who live with a higher risk for bladder cancer anyway.” Research suggests that the risk for bladder cancer in diabetics is compounded by the drug Actos.

To learn more about the new biomarker study, including just how accurate the test may be, see New Biomarkers May Advance Bladder Cancer Diagnosis and Treatment, now available on the Cancer Monthly website.

Shabayek, MI et al, “Diagnostic evaluation of urinary angiogenin (ANG) and clusterin (CLU) as biomarkers for bladder cancer”, April 3, 2014, Pathology and Oncology Research, Epub ahead of print,

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