Indian Tree Bark Extract Shows Promise in Improving Athletic Performance

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Research published in the American Journal of Therapeutics shows an extract from the tree Terminalia arjuna, distributed as a supplement by Prinova, increased cardiovascular efficiency and improved cardiac conditioning.



This study successfully demonstrates the extract’s ability to enhance the performance and protect the heart in young exercising adults.

An extract from the tree Terminalia arjuna significantly increased cardiovascular efficiency and improved the cardiac conditioning in young healthy male adults, according to research published in the American Journal of Therapeutics.

Oxyjun™ is a proprietary extract, standardized to polyphenols and glycosides used in the study. It was developed by Enovate Biolife and was supplied by IN Ingredients. Prinova is the exclusive North American distributor for all of IN’s clinically proven trademarked ingredients, including Cinnulin PF®, Lanconone®, Clock® and many more.

The researchers, Robert N. Girandola, Ed.D., from the University of Southern California, Los Angeles and Shalini Srivastava, from Enovate Biolife, Wilmington, Del., developed a double-blind randomized trial with 32 health males.

The researchers hypothesized that Terminalia arjuna, which has a history of cardiovascular benefits, could be used to extend cardiac performance and safely allow people to exercise for longer time periods with less fatigue. Therefore, a double-blind randomized trial with 32 healthy male subjects was developed. Each subject was given either 400 mg of Oxyjun™ or placebo. The exercise protocol involved a one-minute warm up at three miles per hour followed by an increase of two percent and one mile per hour increase in grade and speed, respectively, every three minutes until the subjects volunteered that the exercise was too difficult to continue. The researchers then assessed the left ventricular ejection facture, right ventricular myocardial performance index, and Borg Rated Perceived Exertion (RPE) at baseline, day 28, and day 56. Cardiac biomarkers creatine kinase enzyme and cardiac troponin-T were assessed, two biomarkers considered gold standards for cardiomyocyte insult.

At 56 days supplementation, the Oxyjun™ group reported that the exercise conducted was easier and less stressful than the placebo group. The Oxyjun™ group experienced significant improvement in cardiac conditioning during their exercise, which was associated with improvement of the measured exercise performance.

Extracts from the Indian tree Terminalia arjuna have been used in India for centuries to support cardiovascular health. Terminalia arjuna has been long thought to have medicinal properties but its safety and efficacy has not been thoroughly studied in the United States.

According to a review published by the Journal of Traditional and Complementary Medicine, most of the studies of Terminalia arjuna have suggested that it provides antioxidant benefits, as well as support to the blood vessels and blood lipids.

“Based on the findings of the study, we deduce that the E-OJ-01 (TA extract as Oxyjun™) improved various central factors for physical endurance such as left ventricular ejection fraction, time to exhaustion and Borg RPE score. It also decreases RV-MPI which is an important determinant for cardiac musculature size. With the increase in the cardiac output as well as a reduction in MPI, it is expected that VO2 max levels would also be increased. Additional cardiac biomarkers showed normal levels throughout the study. This study successfully demonstrates the extract’s ability to enhance the performance and protect the heart in young exercising adults,” said Dr. Girandola.

About Prinova USA: Since 1978, Prinova has been a leader in providing high-quality ingredients, flavors and value-added nutrient fortification products to the global food, feed and wellness industries. Prinova holds strategic stocks in 15 distribution centers around the world to ensure continuity of supply and is the leading global supplier of Vitamin C, B and food grade Amino Acids. The company also has a team of application and technical specialists within their R&D and Quality Laboratory to help customers develop, improve, and enhance the taste and function of their products. Prinova’s facilities are BRC certified. The company’s main corporate office is in Carol Stream, Illinois with the European head office in the United Kingdom and a regional office in Canada. Additional regional offices are located throughout the United States as well as global sales associates in Mexico, Spain, Germany, Belgium, France, Turkey and China.

IN Ingredients, formerly Integrity Nutraceuticals, was founded by Tim Romero and Lloyd Slabach in 1999. The company was formed based on the premise of Integrity. The founders were and are committed to operating a business that would honor God while serving others. Adopting the Biblical principle of the “Golden Rule”, to treat others as you wish to be treated, their vision was to be a raw material supplier dedicated to integrity, quality, dependability and service. After evaluation of the business in mid-2013, the owners of Integrity decide it was best for two owners to devote their time to the ingredients division to further growth and capitalize on the IP portfolio that existed and continues to build. Tim Romero and Gus Romero were up for the challenge and so in September of 2013 they launched an ingredients venture, entitling it IN-Ingredients. It’s the same vision and strategy with a new name and a facelift. All of IN’s incoming raw materials are qualified in an in-house laboratory equipped with the latest in analytical technology. They are committed to our rigorous quality assurance systems to provide customers with the best possible products.

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