Lexogen Showcases Analysis of the Transcriptome of Carriers of Pathological Variants That Cause Alzheimer's Disease

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In this webinar, which LabRoots will host June 8, attendees will become familiarize with digital deconvolution and network analysis techniques that allow to validate results when analyzing dataset with a reduced number of samples.

Oscar Harari, PhD Assistant Professor in the Department of Psychiatry in Washington University in St Louis

Alzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in molecular networks linking a host of biological processes. A variety of genetic factors have been shown to contribute to risk with varying degrees of penetrance. Variants in these genes confer a different transcriptomic profile, and mutation carriers clustered separately from their non-carrier siblings.

New evidences provide support for both neuronal and glial specific pathways contributing to pathogenesis. However, little is understood about how the genetic loci and molecular changes are organized into common networks. Understanding variant-specific effects is of an immense importance for the elucidation of the underlying biology of the Alzheimer Disease. Initial analysis reveals a transcriptional regulation module that link that early-onset autosomal dominant and late-onset sporadic genes.

In this webinar, participants will learn to identify confounding factors that can affect transcriptomic analyses and learn how to address them. They will also learn digital deconvolution approaches to infer cell composition from RNA-seq data and how transcriptomic profiles can reveal gene co-expression networks.

The speaker for this webinar will be Dr. Oscar Harari, an assistant professor in the Department of Psychiatry in Washington University in St Louis.

He received a doctorate in artificial intelligence from the University of Granada, and he was trained in genetics of neurodegeneration in the Lab of Alison Goate, Department of Psychiatry, Washington University in St Louis during his postdoc. In his current role he is the associate professor in the Department of Psychiatry in Washington University in St Louis, where his research is focused in the identification of omics factors implicated in complex neurodegenerative traits; in particular Alzheimer Disease.

LabRoots will host the event June 8, beginning at 10 a.m. PDT, 1:00 p.m. EDT, 7:00 p.m. CEST. To read more about this event, learn of the continuing education credits offered, or to register for free, click here.

About Lexogen:    
Lexogen is a transcriptomics and Next Generation Sequencing (NGS) company, focusing on the development of technologies for complete transcriptome sequencing. Its portfolio includes innovative molecular biology kits, software, and services for RNA-Seq.

Lexogen offers two types of sequencing library preparation kits. SENSE kits are for whole transcriptome sequencing and are suitable for anaylsis of mRNA and total RNA from intact RNA samples, as well as highly degraded and FFPE samples. QuantSeq library preparation kits are for 3’ mRNA-Seq and target-specific sequencing. All library preparation protocols are based on Lexogen’s proprietary technologies which eliminate the need for RNA or cDNA fragmentation, allowing to preserve superior strand-specificity (>99.9%) and enabling exceptionally rapid turnaround times.

Other products include SPLIT RNA Extraction Kit, TeloPrime Full-Length cDNA Amplification Kit, RiboCop rRNA Depletion Kit, Spike-in RNA Variant Control Mixes (SIRVs), and Mix2 RNA-Seq Data Analysis Software for highly accurate concentration estimates of gene isoforms. Lexogen is based in Vienna, Austria, and has a subsidiary in Greenland, NH, US.

LabRoots is the leading scientific social networking website, which provides daily scientific trending news and science-themed apparel, as well as produces educational virtual events and webinars, on the latest discoveries and advancements in science. Contributing to the advancement of science through content sharing capabilities, LabRoots is a powerful advocate in amplifying global networks and communities. Founded in 2008, LabRoots emphasizes digital innovation in scientific collaboration and learning, and is a primary source for current scientific news, webinars, virtual conferences, and more. LabRoots has grown into the world’s largest series of virtual events within the Life Sciences and Clinical Diagnostics community.

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Karen Sorenson
LabRoots, Inc.
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