Accessibility Statement Skip Navigation
  • Why PRWeb
  • How It Works
  • Who Uses It
  • Pricing
  • Login
  • GDPR
  • Create a Free Account
Return to PRWeb homepage
  • News
  • Resources
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All News Releases
      • Multimedia Gallery

      • All Multimedia
      • All Photos
      • All Videos
  • Business & Money
      • Auto & Transportation

      • Aerospace, Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads and Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking and Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers and Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalization
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls and Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil and Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defense
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation and Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking and Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers and Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines and Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics and Personal Care
      • Fashion
      • Food & Beverages
      • Furniture and Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewelry
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks and Tourist Attractions
      • Gambling & Casinos
      • Hotels and Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Advocacy Group Opinion
      • Animal Welfare
      • Congressional & Presidential Campaigns
      • Corporate Social Responsibility
      • Domestic Policy
      • Economic News, Trends, Analysis
      • Education
      • Environmental
      • European Government
      • FDA Approval
      • Federal and State Legislation
      • Federal Executive Branch & Agency
      • Foreign Policy & International Affairs
      • Homeland Security
      • Labor & Union
      • Legal Issues
      • Natural Disasters
      • Not For Profit
      • Patent Law
      • Public Safety
      • Trade Policy
      • U.S. State Policy
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Hamburger menu
  • Cision PRWeb provides efficient communication tools to continuously engage with target audiences across multiple online channels
  • Create a Free Account
    • ALL CONTACT INFO
    • Contact Us


      11AM ET Sunday – 8PM ET Friday

  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • News in Focus
    • Browse All News
    • Multimedia Gallery
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR

Safety Concerns Over Active Surveillance for Intermediate-risk Prostate Cancer
  • USA - English


News provided by

Dr. David Samadi

Aug 08, 2017, 03:00 ET

Share this article

Share toX

Share this article

Share toX

Shared and informed decision making is the core in treatment of prostate cancer
Shared and informed decision making is the core in treatment of prostate cancer
Youtube
Youtube

(PRWEB) August 08, 2017 -- A recent cohort study from Harvard Medical School published in European Urology Focus found nearly one in three men with Gleason 3 + 4 favorable intermediate-risk (FIR) prostate cancer (PCa) after having had a radical prostatectomy harbored a higher grade or stage of the disease than previously thought raising concerns about the safety of managing PCa with active surveillance (AS).

If at any time a man is uncomfortable with active surveillance, he should express that concern as we can together agree on which treatment method is best for him

Post this

“Active surveillance has been an option for monitoring cancer closely with the goal to allow a man to have the highest quality of life while delaying or possibly even completely avoiding invasive treatments,’ said Dr. David Samadi. “It can certainly be a viable method for monitoring men with prostate cancer that falls into the category of being low-grade or is considered to be very slow growing and not likely to spread. This study, however, found that some men who fall into this category may be concealing worse disease than what their prostate biopsy or clinical exam may be showing, meaning active surveillance may not be appropriate for them.”

The objective of this study was to examine the incidence and predictor of upgrading and upstaging among men with Gleason 3 + 4 FIR disease since it was unknown whether the active surveillance was always a safe option for patients with this stage of PCa. Using the National Cancer Database, the researchers studied more than 10,000 men diagnosed during 2010-2012 with Gleason 3 +4 tumors, with a prostate specific antigen (PSA) below 10 ng/mL, and CT1c-2c PCa with fewer than 50% positive biopsy cores who underwent radical prostatectomy.

“What the researchers found was that 30.3% of men with a Gleason score of 3 + 4 favorable intermediate-risk prostate cancer harbored advanced disease of a higher grade or stage,” explained Dr. Samadi. “The current guideline from the American Society of Clinical Oncology endorses the use of AS for select patients with low-volume Gleason 3 + 4 disease. What these findings suggest is that older men with a Gleason 3 + 4 FIR disease and who have a high PSA, a high percentage of positive biopsy cores and or a cT2a stage cancer would not be good candidates for active surveillance. The study found that with these combined factors, they were able to identify groups of men whose risk of upgrading or upstaging ranged from just over 20% to nearly 50%. According to this study, active surveillance would not be a method of treatment I would feel comfortable in recommending unless their life expectancy is already low.”

From the study, the researchers stated the strongest predictors of upgrading and upstaging were PSA and percentage positive biopsy cores. The reason for this was that the risk of upgrading or upstaging increased from 21.7% for patients with fewer than 12.5% positive cores and PSA level of 4.0 ng/mL or below to 44.3% for men with 37.5%-49.9% positive cores and a PSA level of 8.1-9.9 ng/mL.

“Men who are good candidates for active surveillance are younger patients with a low PSA, low percentage of positive cores, and cT1c tumors as they have a 20% risk of a more progressive disease,” explained Dr. Samadi. “They would still require close monitoring and follow-ups involving regular PSA measurements, repeat biopsies, and other means of therapy such as magnetic resonance imaging of the prostate if there are concerns of growing cancer.”

Dr. Samadi went on to add, “Men with prostate cancer who are being treated with active surveillance, are seen on a regular basis in which I am checking and evaluating the tumor for any signs of change. If I discover changes are occurring such as a rise in a man’s PSA level or Gleason score, then I would recommend stopping active surveillance and begin another form of treatment based on my findings. My goal is to determine if active surveillance is the right treatment for each man I see. As long as the cancer is confined to the prostate and does not appear to be aggressive, it can be advantageous as it can help delay or avoid potential side effects of surgery or radiation therapy. However, if at any time a man is uncomfortable with active surveillance, he should express that concern as we can together agree on which treatment method is best for him.”

Patients newly diagnosed with prostate cancer can contact world-renowned prostate cancer surgeon and urologic oncologist, http:// Dr. David Samadi, for a free phone consultation and to learn more about prostate cancer risk, call 212-365-5000.

David Samadi, MD, Dr. David Samadi, +1 (212) 365-5000, [email protected]

Modal title

Contact PRWeb

  • 11AM ET Sunday – 8PM ET Friday
  • Contact Us

About PRWeb

  • About PRWeb
  • Partners
  • Partnership Programs
  • Editorial Guidelines
  • Resources

Why PRWeb

  • Why PRWeb
  • How It Works
  • Who Uses It
  • Pricing

Accounts

  • Create a Free Account
  • Log in
  • Contact Us

Do not sell or share my personal information:

  • Submit via [email protected] 
  • Call Privacy toll-free: 877-297-8921

Contact Cision

Products

About

My Services
  • All News Releases
  • Online Member Center
  • ProfNet
Cision Distribution Helpline
888-776-0942
  • Legal
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 Cision US Inc.