Oxford Biomedical Research Awarded NIH Grant to Expand Its Express™ Line of Biocatalysts

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Oxford Biomedical Research, Inc., a privately held biotechnology company located in Oakland County Michigan, has been awarded a $214,396 Phase 1 Small Business Innovation Research Grant by the National Institute of General Medical Sciences. This grant, entitled “A New Co-Expressed P450 and UGT Platform for Simultaneous Preparation of P450 Metabolites and Their Glucuronides,” will further expand Oxford’s line of recombinant human biocatalysts designed for rapid, inexpensive production of drug metabolites and analogues.

Toxins, pharmaceuticals and many endogenous compounds are metabolized by several classes of enzymes. Oxford has already developed an extensive line of key detoxifying enzymes, including cytochromes P450 and Glutathione-S-Transferases. Uridine diphosphate glucuronosyltransferase (UGT) enzymes also play key roles in the metabolism of drugs and toxins, but few UGTs are commercially available.

Oxford has developed a proprietary method for producing recombinant enzymes in a novel format – a thermostable dry powder that readily hydrates to give a semipermeable catalytic system that is well-tailored to pharmaceutical research. This system exhibits remarkable organic solvent and thermal tolerance along with extended catalysis when compared to traditional recombinant enzymes. This grant will allow Oxford scientists to advance its technology to provide multi-catalytic platform, capable of simultaneous P450 oxidation followed by synergistic glucuronidation. The platform will also include accessory enzymes required to provide the cofactors required for P450 and UGT enzymes – thereby significantly reducing the cost and complexity of glucuronide production.

This research, led by Dr. Enrique Martinez, will give pharmaceutical scientists a robust, easy-to-use system for performing two metabolically-important reactions in one system; P450 oxidation followed by UGT glucuronidation.

Oxford Biomedical Research, Inc. develops, manufactures, and markets products for biomedical research, companion animal veterinary diagnosis and food quality testing.

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Richard McGowen
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