Biomonitoring: Relevance of Bioassays in Water Treatment, Upcoming Webinar Hosted by Xtalks

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In this free webinar, the featured speaker will discuss bioassay selection that can address cellular toxicity pathways, including receptor-mediated events, such as endocrine-disrupting chemicals. Attendees will learn about complementing chemical analysis of water quality with bioanalytical tools for the detection of chemicals at low concentration, as well as the quantitation and interpretation of cell-based bioassays.

The aim of this presentation is to identify bioassays commonly applied to water extracts and provide guidance on assay selection and subsequent interpretation.

Human-impacted surface, ground and drinking water can contain a complex mixture of micropollutants, such as pharmaceuticals, pesticides and industrial compounds. These potentially harmful chemicals are often found at low concentrations, and targeted chemical analysis cannot detect all the hazards present in a sample. Suspect screening and non-target analysis can identify a larger number of compounds but cannot provide information about the potential toxic effects of the micropollutant mixture.

Bioassays can account for mixture effects that targeted chemical analysis can miss and are risk-scaled as more potent chemicals have a greater effect in the assay. Consequently, effect-based methods have been recommended to complement chemical analysis in water quality monitoring. Bioassays based on different stages of cellular toxicity pathways including induction of xenobiotic metabolism, receptor-mediated effects, adaptive stress responses and apical effects have been widely applied to evaluate the effect of different water extracts.

The aim of this presentation is to identify bioassays commonly applied to water extracts and provide guidance on assay selection and subsequent interpretation. Examples will be given for how cell-based assays have been utilized to analyze important chemicals of concern, as well as complex mixtures. Data analysis including bioanalytical equivalent concentrations (BEQ), limit of detection (LOD) and effect concentration (EC) will be described.

Register for this webinar to discover how cell-based assays can help improve water quality assessments with an emphasis on potential health effects of complex mixtures of micropollutants.

Join Jack Vanden Heuvel, Professor of Molecular Toxicology, Penn State University and CSO, INDIGO Biosciences for the live webinar on Thursday, December 9, 2021 at 1pm EST.

For more information, or to register for this event, visit Biomonitoring: Relevance of Bioassays in Water Treatment.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year, thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit http://xtalks.com
For information about hosting a webinar visit http://xtalks.com/why-host-a-webinar/

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Sydney Perelmutter
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