In this free webinar, learn how to maximize net titres in bioprocessing through an integrated approach that combines high titre production with efficient downstream processing. Attendees will gain insights into the pitfalls of overreliance on high titre compared to net titre. The featured speakers will discuss the reality of the limitations of existing market offerings and circumstances when this could have critical implications for projects. Attendees will learn about the importance of an integrated approach to mitigate pitfalls and maximize net titre. The speakers will also discuss how custom strain development and CGMP biomanufacturing excellence can result in an attractive partnership for customers.
TORONTO, Aug. 8, 2024 /PRNewswire-PRWeb/ -- In advanced bioprocessing, achieving high titres in microbial production is celebrated. However, the ultimate measure of success lies in the net titre, which considers both efficiency and yield as the protein moves through and out of downstream processing (DSP).
Traditional bioprocessing methods prioritize optimizing expression systems for high titres using standard host cells like Chinese hamster ovary (CHO) or Pichia pastoris. While effective initially, these methods frequently fall short in net yield due to inefficiencies in DSP. Complex purification processes, increased costs and reduced efficiency often result from high initial titres.
Balancing impressive initial titres with the practical economic realities of purification and overall yield is a critical challenge faced by drug developers with clinical manufacturing aspirations. These limitations underscore the necessity for a comprehensive bioprocess optimization strategy integrating both upstream and downstream processes.
In this webinar, the speaker will share how an integrated approach maximizes net titre by combining high titre production with efficient DSP. This involves optimizing the genetic and metabolic pathways of host cells and refining downstream processes to minimize product loss. Techniques such as quantitative trait loci (QTL) technology and advanced synthetic biology enhance strain robustness, improving production, lowering production costs and enhancing yield. Compared to traditional methods, this integrated strategy ensures high titres translate into commercially viable and sustainable net yields.
Register for this webinar today to understand how to maximize net titres in bioprocessing through an integrated approach that combines high titre production with efficient downstream processing.
Join experts from Phenotypeca Limited, Professor Ed Louis, PhD, R&D Director; and Johnny Cordiner, CEO, for the live webinar on Wednesday, August 28, 2024, at 10am EDT (4pm CEST/EU-Central).
For more information, or to register for this event, visit Bioprocessing Economics: High Titre for Show, Net Titre for Profitable Growth.
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