Breakthrough Cancer Drug Delivery Platform with Direct Active Entry into the Lymphatic System presented via Hidden GEMS Program from One Million Solutions in Health

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Through its Hidden GEMS Program and this science developed by the NIH, One Million Solutions in Health offers the chance to learn about licensing new science that could significantly benefit the development of both new and current cancer drugs.

Breakthrough Cancer Drug Delivery Platform with Direct Active Entry into the Lymphatic System

Cancer Drug Delivery Platform with Direct Active Entry into the Lymphatic System

Dr. Stephan T. Stern has developed this Polylysine Succinate platform which has the ability to replace liposome and micellar systems, and become the new Gold Standard.

For this breakthrough cancer drug delivery platform with direct active entry into the lymphatic system, One Million Solutions in Health, via their Hidden GEMS Program, partnered with the United States' National Institutes of Health Office of Technology Transfer (NIH-OTT) and the National Cancer Institute Technology Transfer Center (NCI-TTC) to spread awareness of NIH technologies and advances, with the goal being to commercialize this new science through licensing agreements.

Dr. Stephan T. Stern shares his work in this scientific presentation and licensing opportunity review which is spearheaded by One Million Solutions in Health. During his presentation which is entitled “NIH Licensing Opportunity: Breakthrough Cancer Drug Delivery Platform with Direct Active Entry into the Lymphatic System” scientific scouts, business leaders and commercialization experts are provided with the opportunity to acquire knowledge about the latest science and technology directly from the NIH scientist.

In this scientific and opportunity presentation, those attendees with strong knowledge about this market and the scientific need for new technology can also take part in One Million Solutions in Health's exclusive Signature Square process where they are able to assess the innovation, make inquiries and give open feedback to the scientist.

This licensing opportunity demonstrates through Dr. Stern's presentation how this Polylysine Succinate (PLS) platform is superior to liposome and micellar drug delivery systems. New therapeutics could use less drug, with less side effects and higher efficacy. For current therapeutics, this could extend the patent life. This PLS platform has the ability to replace liposome and micellar systems, and become the new Gold Standard.

This technology is directed to a polylysinesuccinate (PLS) based polymeric drug delivery platform that delivers a therapeutic cargo (e.g., small molecule drugs, therapeutic peptides, and vaccines) to the lymphatic system and myeloid/antigen presenting cell (APC) sub-populations. The PLS-based delivery platform specifically targets scavenger receptor A1 (SR-A1), a receptor highly expressed in macrophages, monocytes, mast cells, dendritic cells (myeloid lineages), and endothelial cells. Unlike currently available therapeutics that target the lymphatic system through passive diffusion through porous vasculature, this novel PLS delivery platform selectively targets the lymphatic system through SR-A1 mediated transcytosis.

The PLS delivery platform has superior stability and release characteristics, compared to currently available therapeutics targeting the lymphatic system, releasing the therapeutic payload in a manner that results in a superior therapeutic effect.

This scientific presentation is an opportunity to license this technology, or participate in further collaborative work to enhance its development.

The Technology Evaluation Consortium, which plays a role in evaluating new technologies such as this, includes organizations such as Pfizer, AbbVie, Amgen and Allergan, and many others.

The goal of One Million Solutions in Health is to shape health care by sharing solutions and, importantly, to accelerate the discovery, development and delivery of innovative cures, treatments and preventative measures for patients around the world.

In this next year through the Hidden GEMS Program, we will be reviewing 100's of new solutions and new scientific discoveries. By engaging scientists, entrepreneurs, investors, innovators, industry experts, health care professionals, and patients across various disciplines, and from around the world, we can utilize the power of the internet to disrupt things in a positive and transformative way to accelerate the movement of new solutions and scientific discoveries from the scientist to the patient.

We are on our way towards accelerating high-potential innovations, catalyzing investment and increasing awareness of, and support for, transformative ideas to improve health and save lives. By facilitating efforts to ensure organizations can Connect, Learn + Share, Innovate and Collaborate, our vision is to improve health care delivery, accelerate life sciences research, and share patient and consumer-focused ideas and solutions.

As a not-for-profit, we welcome your participation and are thrilled to have you be a part of this transformative journey.

Through the Hidden GEMS Program, the Technology Evaluation Consortium from One Million Solutions in Health is dedicated to improving and accelerating life sciences R&D and health care outcomes. The Technology Evaluation Consortium brings together life sciences and/or health care companies and industry vendors or scientists, and other relevant partners (e.g., government and Universities), to evaluate and validate technologies or services in a collaborative environment.

The model empowers technology providers/scientists and industry end-users to collectively assess a number of solutions in a cost-effective manner, producing a depth and breadth of results that no company can achieve alone. Our mission is to triage and streamline new technology consideration for the industry and to be the place for the industry to conduct their evaluations and validations.

To obtain further information about licensing or co-development opportunities OR to have One Million Solutions in Health help your Technology Transfer office bring more of your research to market by obtaining more licensing deals via the Hidden GEMS Program, contact:

Dawn Van Dam, Executive Director
One Million Solutions in Health

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