Challenges and Solutions in Host Cell Protein ELISA Development, Upcoming Webinar Hosted by Xtalks

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In this free webinar, the featured speakers will discuss the similarities and differences between generic and specific HCP ELISA formats and when to use them, as well as the importance of selecting suitable antigen material. Attendees will learn about powerful polyclonal antibody generation, including the surveillance of proper immune reaction, adjusted purification strategy, strategies for the determination of the antibody coverage and criteria for the ELISA development.

Host Cell Proteins (HCPs) pose a common challenge to biopharmaceutical manufacturers as residual HCP can negatively influence the quality, safety and efficacy of drug products. The stepwise Downstream Processing (DSP) aims to purify the drug substance and requires the reliable monitoring of potential HCP impurities. This is usually carried out by an HCP ELISA as the method of choice, enabling an HCP measurement down to low ppm level. This method is based on antibodies that specifically detect HCP species in user-defined DSP samples which contain the drug substance. During ELISA development at BioGenes, a list of critical aspects is used to generate a powerful HCP assay. This includes the correct choice of a suitable mock antigen, a sophisticated immunization strategy, comprehensive reagent characterization and a targeted ELISA set-up.

Join featured speakers from BioGenes, Stefan Sommerschuh, Head of Assay Development; Pia Paarmann, PhD, Head of 2D Analytics; and Martin Föge, PhD, Business Development Manager, in a live webinar on Thursday, November 19, 2020 at 11am EST (4pm GMT/UK).

For more information, or to register for this event, visit Challenges and Solutions in Host Cell Protein ELISA Development.


Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year, thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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Sydney Perelmutter
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