In this free webinar, learn how dose-by-dose adherence monitoring with digital tools and timely interventions can significantly increase patient retention and improve overall compliance in CNS trials. Attendees will gain insight into how active, daily adherence monitoring with a built-in review service offers advantages over traditional adherence solutions. The featured speakers will share the real-world challenges that patients face in adhering to protocols, managing medication and using digital tools. The speakers will also discuss how a technology-enabled service can improve trial efficiency and strengthen confidence in data integrity.
TORONTO, July 3, 2025 /PRNewswire-PRWeb/ -- Adherence is one of the most persistent challenges in CNS trials, particularly in studies involving controlled substances. This webinar examines how a Phase II study in major depressive disorder (MDD) addresses this issue directly, utilizing a digital, patient-centred solution.
The SOLEO trial, an ongoing Phase II study evaluating oral esketamine (CLE-100), integrates Scene Health's Video Directly Observed Therapy (VDOT) Adherence Service to support daily patient compliance. Using asynchronous video capture and real-time human review, the system enables the timely identification of missed doses, potential misuse and patients at risk of dropout — ultimately improving protocol adherence, medication accountability and patient retention.
Drawing on operational insights from the trial site, sponsor and technology provider, this case study highlights practical considerations for implementing a tech-enabled adherence model in CNS trials. It also examines how digital health tools can enhance data integrity, reduce protocol deviations and support more efficient therapeutic development.
Featuring a panel of experts from the trial site (a Clinical Trials Manager, CenExel Research), the pharmaceutical sponsor (Medical Director, Clexio Biosciences) and the technology provider (Chief Strategy Officer, Scene Health), this session offers a valuable perspective for medical directors, trial operations leads and innovation officers at pharmaceutical companies and CROs.
Join the featured speakers to explore how:
- Digital adherence tools are being used in real-time to improve protocol compliance and reduce patient dropout in CNS trials
- A human-in-the-loop review model can detect and escalate non-compliance faster than traditional methods
- Understanding the patient experience with digital tools can improve engagement and long-term retention
- Technology-enabled adherence services can reduce protocol deviations and support more reliable data
Register for this webinar now to gain a comprehensive understanding of how digital health solutions are reshaping the landscape of CNS trials, delivering more reliable data, enhancing patient safety and driving greater overall trial success.
Join Esther Hagai, MD, PhD, Chief Medical Officer, Clexio Biosciences Ltd.; Morgan Hecker, Clinical Trials Manager, CenExel iResearch Atlanta; and Morad Elmi, Co-Founder, Chief Strategy Officer, Scene Health, for the live webinar on Wednesday, July 16, 2025, at 12pm EDT (5pm BST/UK).
For more information, or to register for this event, visit CNS Trials: Lessons in Adherence Monitoring from a Phase II Study.
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