In this free webinar, learn strategies to produce robust controlled-release tablets for the most challenging high-throughput commercial tableting conditions. Attendees will learn about the impact of strain rate sensitivity on compression, tablet strength and weight uniformity. The featured speaker will discuss strategies to improve API and formulation stability by reducing the potential for nitrosamine formation.
TORONTO, March 21, 2023 /PRNewswire-PRWeb/ -- Demand is driving the need for high-volume, high-speed tablet presses and this calls for improved manufacturing efficiency. Such presses subject materials to a higher strain rate, which creates challenges with tablet strength, weight uniformity and scale-up from lab to commercial manufacturing. Understanding the strain rate sensitivity of the API and excipients plays a critical role in tablet robustness, especially in the formulation of controlled-release dosage forms.
Hypromellose (hydroxymethyl cellulose) is the leading matrix-forming polymer in controlled-release tablets. It is often and typically used at levels between 20 and 30 percent, and therefore can significantly impact the formulation's physical characteristics.
Ashland's Benecel™ xrf hpmc, with lower nitrosamine levels, can improve formulation stability by minimizing the potential for interaction between API and excipients that results in N-nitrosodimethylamine (NDMA), a nitrosamine impurity. Recent drug recalls have been caused due to higher nitrosamine levels in the dosage form resulting from such interactions.
Register to learn about the optimization of controlled-release formulations for high-speed, high-throughput manufacturing, with specific focus on improving efficiency and API stability.
Join Kapish Karan, MS, Global OSD R&D Leader, Pharmaceuticals, Ashland, for the live webinar on Wednesday, April 12, 2023, at 10am EDT (4pm CEST/EU-Central).
For more information, or to register for this event, visit Controlled-Release Formulations: Improving Stability and Efficiency.
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Contact:
Vera Kovacevic
Tel: +1 (416) 977-6555 x371
Email: [email protected]
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Vera Kovacevic, Xtalks, +1 (416) 977-6555 x371, [email protected]
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