Creating reliable animal models for long-term studies can often be problematic, not necessarily due to the complexity of the genetic modification(s) required, but with how that genetic modification will perform in the model.
TORONTO (PRWEB) June 18, 2020
Nuclease-based technologies such as CRISPR and ZFN have simplified the way we genetically engineer new models. However, while modifying the genome may be more straightforward, the challenge to create an optimal model for the desired application remains. Creating reliable animal models for long-term studies can often be problematic, not necessarily due to the complexity of the genetic modification(s) required, but with how that genetic modification will perform in the model. Suboptimal design strategies can compound these challenges by generating undesired genotypic or phenotypic results thus producing an ineffective model.
CRISPR-Cas9 or zinc-finger nuclease (ZFN)-based technologies can circumvent the challenges of complex genetic alterations due to their precision. When focusing on what the exact need or application will be for the model, optimal designs can be determined that then yield a reliable model for its specific application. Whether the modification to be produced is a humanization, replacement, conditional knockout, constitutive knockout, large deletion, point mutation, cDNA insertion, or reporter tagging, if careful consideration is given to the goal for the model usage and application, then optimal designs yield superior models.
When considering new model creation and development, scientists often focus on generating the model itself and overlook the downstream services required afterward, including initial model characterization, cryopreservation, breeding, and colony expansion. Envigo is the scientist alongside their customers – taking in all considerations for the model application and all the products and services needed to create, develop, and maintain the model.
For more information or to register for this event, visit CRISPR Generated Models: A Framework for Reducing Risk and Timelines Through Careful Design and Planning for Downstream Services.
Envigo provides the broadest range of research models and related services to the pharmaceutical and biotechnology industries, government, academia, and other life science organizations. As the largest organization that is solely dedicated to providing research models and related products and services, we are committed to helping researchers realize the full potential of their critical R&D projects as we fulfill our mission to work together to build a healthier and safer world. Read more at envigo.com.
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