Growing a sufficiently large, good quality, single crystal can sometimes still be a challenge and a bottleneck, even when crystals smaller than 100-μm can now routinely be used.
TORONTO, Ontario (PRWEB) September 11, 2020
Single crystal structure solution using X-ray diffraction analysis (SC-XRD) plays an important role in drug development. SC-XRD fully elucidates the molecular structure and can be used to confirm successful chemical synthesis of the molecule. Many drug molecules are chiral. In addition to being the most reliable, SC-XRD is the only generally applicable method to determine the absolute configuration, i.e. the three-dimensional structure of the molecular bonds.
Growing a sufficiently large, good quality, single crystal can sometimes still be a challenge and a bottleneck, even when crystals smaller than 100-μm can now routinely be used. Several growing techniques will be discussed in this upcoming webinar.
Given high resolution powder X-ray diffraction (PXRD) data, most often the unit cell parameters and space group can be determined by finding an indexing solution to the observed peak positions, also known as indexing. The resulting unit cell volume can be used to identify the contents and stoichiometry, and the index of a PXRD pattern reveals if extraneous Bragg peaks exist, indicating form impurities.
In patents, solid forms are usually claimed by lists of characteristic peaks in the PXRD. Collecting PXRD data is often straightforward, though pitfalls exist.
Join this webinar to learn more!
For more information or to register for this event, visit Crystal Structure Determination in Solid Form Drug Development.
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