The gold standard has been ligand binding assays (LBA), but liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is emerging as a promising alternative for biologics quantification.
TORONTO (PRWEB) October 28, 2020
Over the past 20 years, protein and peptide drug development has evolved considerably and made a significant impact on the biotherapeutic market. This expansion into biologics has pushed pharmaceutical companies and contract research organizations (CROs) to explore new approaches for efficiently quantifying these large molecules to support high throughput, early stage pharmacokinetic (PK) studies. The gold standard has been ligand binding assays (LBA), but liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is emerging as a promising alternative for biologics quantification.
Especially for compounds in early stages of drug development, LC-MS/MS offers multiple advantages over LBA such as multiplexing capability, higher selectivity, and faster method development. In addition, LC-MS/MS is an attractive alternative at early stages since the availability of specific reagents needed for LBA assays can be limited.
This webinar will highlight current challenges and emerging opportunities for the discovery environment.
Join Salinda Wijeratne, PhD, Staff Scientist I, Discovery Bioanalytical, Covance and Lisa Geisler, PhD, Global Discovery Manager, Bioanalytical Chemistry, Covance in a live webinar on Thursday, November 12, 2020 at 11am EST (4pm GMT/UK).
For more information or to register for this event, visit Discovery Bioanalysis: Current Challenges and Emerging Opportunities for Biologics Quantification by LC-MS.
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