Accessibility Statement Skip Navigation
  • Why PRWeb
  • How It Works
  • Who Uses It
  • Pricing
  • Login
  • GDPR
  • Create a Free Account
Return to PRWeb homepage
  • News
  • Resources
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All News Releases
      • Multimedia Gallery

      • All Multimedia
      • All Photos
      • All Videos
  • Business & Money
      • Auto & Transportation

      • Aerospace, Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads and Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking and Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers and Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalization
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls and Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil and Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defense
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation and Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking and Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers and Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines and Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics and Personal Care
      • Fashion
      • Food & Beverages
      • Furniture and Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewelry
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks and Tourist Attractions
      • Gambling & Casinos
      • Hotels and Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Advocacy Group Opinion
      • Animal Welfare
      • Congressional & Presidential Campaigns
      • Corporate Social Responsibility
      • Domestic Policy
      • Economic News, Trends, Analysis
      • Education
      • Environmental
      • European Government
      • FDA Approval
      • Federal and State Legislation
      • Federal Executive Branch & Agency
      • Foreign Policy & International Affairs
      • Homeland Security
      • Labor & Union
      • Legal Issues
      • Natural Disasters
      • Not For Profit
      • Patent Law
      • Public Safety
      • Trade Policy
      • U.S. State Policy
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Hamburger menu
  • Cision PRWeb provides efficient communication tools to continuously engage with target audiences across multiple online channels
  • Create a Free Account
    • ALL CONTACT INFO
    • Contact Us


      11AM ET Sunday – 8PM ET Friday

  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • News in Focus
    • Browse All News
    • Multimedia Gallery
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR

Exponential Growth Expected for Antibody-drug Conjugates (ADCs) - CDMOs Continue to Play a Major Role in Manufacturing and Co-Development

Major pharmaceutical companies involved in the development of Antibody-drug Conjugates (ADCs) either outsource the manufacturing of their ADC or are collaborating with a Contract Development Manufacturing Organizations (CDMO) in a co-development model. A survey by ADC Review | Journal of Antibody-drug Conjugates again confirms that approximately 70% to 80% of all manufacturing of ADCs is conducted by integrated CDMOs.


News provided by

ADC Review

Nov 13, 2018, 16:55 ET

Share this article

Share toX

Share this article

Share toX


CHANDLER, Ariz., Nov. 13, 2018 /PRNewswire-PRWeb/ -- A survey by the publishers of ADC Review | Journal of Antibody-drug Conjugates showed that in 2017 the global market for antibody therapies reached U.S. $ 4 billion. Approximately forty-five percent of this market included Antibody-drug Conjugates (ADCs). However, in the next few years the market for novel antibody therapies (including ADCs) is expected to grow significantly, to U.S. $ 17 billion by 2023. [1][2][3]

In addition to this exponential growth, the survey also confirmed an ongoing trend of outsourcing manufacturing and/or co-development to integrated Contract Development Manufacturing Organizations (CDMOs). As a result, the survey showed, many CDMOs are expanding their market share.

The supply chain for the manufacturing of Antibody-drug Conjugates (ADCs) is complex. Working with an integrated CDMO speed up the time to market while saving a considerable amount of money.

Post this

To optimize costs, major pharmaceutical companies continue to shed manufacturing assets, driving the need to access specialized capabilities designed to accelerate the commercialization of complex drug candidates such as Antibody-drug Conjugates. In turn, demand for CDMOs with biologics development, manufacturing and regulatory expertise is strong and growing, leading to substantial new investment by these specialized companies.

With approximately 70% to 80% of all ADC manufacturing conducted by CDMOs, major pharmaceutical companies involved in the development of ADCs, including Genentech/Roche, Pfizer, Sanofi, Daiichi Sankyo, Takeda and Seattle Genetics either outsource manufacturing of their ADCs, collaborate with a CDMO in a co-development model or are doing so in the near future. Other companies, including companies like ImmunoGen, have recently shifted their ADC manufacturing to an outsourcing model, saving both time and money.[3]

Manufacturing Challenge
The manufacturing of Antibody-drug Conjugates is complex and requires a cGMP facility designed with the proper engineering controls to provide product and personnel protection from highly potent compounds. This includes, for example, isolators being operated at containment Category 4 designated as Safebridge® to cope with very low occupational exposure limit (OEL). For ADC fill-finish, a fill line with lyophilization capability enclosed in a separate isolator is an additional requirement.

"Contract Development Manufacturing Organizations offer specific technical expertise," says Bethanne Deuel, MBA, Director of Marketing and Alliances at MabPlex International, a CDMO which specializes in the development and cGMP manufacturing of recombinant proteins, antibody therapeutics and Antibody-drug Conjugates for its global customers.

"Working with an integrated CDMO like MabPlex reduces the time to market because we're specialized to perform all key manufacturing steps, from initial R&D through commercial manufacturing and fill-finish. This saves our customers a considerable amount of time and money," Deuel added.

"What's so unique in working with a CDMO like MabPlex is that we have the necessary technological and regulatory expertise, often more than our clients," she concluded.

Currently approved ADCs
Today, there are 4 approved and commercially available ADCs, including Brentuximab vedotin (Adcetris®; Seattle Genetics); Ado-trastuzumab entansine (Kadcyla®; Genetech/Roche); Inotuzumab ozogamicin (Besponsa™, Wyeth Pharmaceuticals, a subsidiary of Pfizer) and Gemtuzumab ozogamicin (Mylotarg™; Wyeth Pharmaceuticals, a subsidiary of Pfizer).

The development these agents has allowed for a more targeted and tumor-specific therapy rather than a non-specific cytolytic chemotherapy or radiation therapy. [4]

Building on their experience, researchers experienced in protein engineering and medicinal chemistry continue to advance these drugs as important therapeutic modalities, both as single agents and as part of various combination regimens with immunotherapeutic agents such as checkpoint inhibitors. And with a large number of Antibody-drug Conjugates in late stage clinical development, the expectation is that, in the next 18 - 24 months, the number of approved and commercially available ADCs will grow exponentially. [5]

What are Antibody-drug Conjugates?
Antibody-drug conjugates (ADC) are a class of innovative and highly potent biopharmaceutical drugs composed of a monoclonal antibody linked, via a chemical linker, to a biologically active drug or cytotoxic (anti-cancer) compound. Often referred to as payload, these cytotoxic agents are designed to induce target cell death when internalized (into the target cell) and released.

By combining the unique and very sensitive targeting capabilities of monoclonal antibodies with the cell-killing ability of their payloads, ADCs are able to deliver highly cytotoxic drug directly to targeted cancer cells without causing 'collateral damage' to 'normal' or 'healthy' cells. As a result, ADCs are designed to overcome the disadvantages of conventional pharmacotherapy based on cytotoxic or immunomodulatory drug, which are not specific to tumor cells, affect normal cells, and may lead to life-threatening side effects.

Although the concept of Antibody-drug Conjugates seems relatively simple, designing a successful, clinically effective, ADCs is complex, requiring careful selection of the receptor antigen, monoclonal antibody, linker chemistry, and cytotoxic payload.

About ADC Review | Journal of Antibody-drug Conjugates
Launched in the summer of 2013 ADC Review | J. of Antibody-drug Conjugates (ISSN 2327-0152) is an international, hybrid open-access, peer reviewed journal designed to serve the needs of a diverse community of individuals involved with the (early) discovery, development, clinical research, manufacturing and legal and regulatory aspects of Antibody-drug Conjugates. The purpose of the Journal is to present relevant information in an understandable and useful format to all stakeholders.[5]

Guided by an Advisory and Editorial Board comprised of scientists, physicians and industry experts/Key Opinion Leaders (KOL) and legal/regulatory experts from a broad range of backgrounds and expertise, the Journal includes news, resources, editorials, and peer reviewed articles.

Recently published peer reviewed articles include a review of progress made in the development of Antibody-drug Conjugates (ADCs – The Dawn of a New Era?), an overview of what we can expect from future developments (ADCs – Look Forward to a Potent Future) and a patent related discussion about Nonobviousness of ADC Inventions.

New Networking Tool: ADC Directory
In addition to the online Journal, the publishers of ADC Review | Journal of Antibody-drug Conjugates recently launched a new networking tool: ADC Directory. The ADC Directory provides a seamless exchange of information between businesses and professionals focused on the research, development and manufacture of antibody-drug conjugates. Members have the opportunity to share reviews, articles, videos, events, products, career opportunities and much more.

About MabPlex International
MabPlex provides global CDMO services in the development and manufacturing of biopharmaceuticals, including mAbs, recombinant proteins, ADCs and bispecifics. The companies offer its partners contract services from DNA to finished drug product. MabPlex technical expertise allows the company to provide effective high quality solutions for its partner's biomanufacturing needs. At both its R&D site in the United States and the manufacturing site in Yantai, China, MabPlex is commitment to partners through the quality of manufacturing, meeting and exceeding their expectations.

Conference Coverage
During the upcoming 9th Annual World ADC Conference, held in the Marriott Marquis & Marina, San Diego, California, November 12 - 15, 2018, one of the best learning experiences in the industry and an ideal forum to stay up to date with the latest developments and progress made in the area of ADCs as well as the opportunity to meet experts, editors of ADC Review | Journal of Antibody-drug Conjugates will be on site for interviews and more. [6]

For more information, or content of which is not part of this press release, please visit ADC Review | Journal of Antibody-drug Conjugates ADC Directory. Contact our business development team for more information about sponsoring and underwriting.

Editorial Office | 4960 South Gilbert Rd, Suite 1-286, Chandler, AZ 85249 (USA)

Reference
[1] ADC Review | J. Antibody-drug Conjugates | Drug Map Online. Last Accessed November 12, 2018
[2] Contract Manufacturing of Antibody-drug Conjugates – A Growing Market. ADC Review | J. of Antibody-drug Conjugates. February 22, 2016. Last Accessed November 12, 2018
[3] CPhI Annual Industry Report 2018: Expert Contribution. Online. Last Accessed November 12, 2018
[4] The Expanding Field of Antibody-Drug Conjugates. Online ADC Review | J. of Antibody-drug Conjugates January 19, 2018. Last Accessed November 12, 2018.
[5] How do ADCs Work. J. of Antibody-drug Conjugates. Last Accessed November 12, 2018
[6] 9th World ADC San Diego: What to Expect. Last Accessed November 12, 2018

SOURCE ADC Review

Related Links

http://www.adcreview.com

Modal title

ADC Drug Map
ADC Drug Map
ADC Directory (Main Page)
ADC Directory (Main Page)
ADC Drug Map ADC Directory (Main Page)

Contact PRWeb

  • 11AM ET Sunday – 8PM ET Friday
  • Contact Us

About PRWeb

  • About PRWeb
  • Partners
  • Partnership Programs
  • Editorial Guidelines
  • Resources

Why PRWeb

  • Why PRWeb
  • How It Works
  • Who Uses It
  • Pricing

Accounts

  • Create a Free Account
  • Log in
  • Contact Us

Do not sell or share my personal information:

  • Submit via [email protected] 
  • Call Privacy toll-free: 877-297-8921

Contact Cision

Products

About

My Services
  • All News Releases
  • Online Member Center
  • ProfNet
Cision Distribution Helpline
888-776-0942
  • Legal
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 Cision US Inc.