By matching mechanism of a drug action with specific disease etiology, precision-medicine approaches are starting to turn the page in CVD trials.
TORONTO (PRWEB) November 30, 2020
Despite advances in medical therapeutics, cardiovascular disease (CVD) remains the leading cause of death worldwide. Notably, heart failure and coronary disease continue to present an exorbitant burden on patients and health care. Recently, breakthroughs in precision medicine are creating optimism for a field that has historically witnessed few long-term successes in targeted therapeutic approaches.
Indeed, precision-medicine approaches target the subsets of patients that are most likely to benefit from a drug, including approaches based on mechanism of disease and shared patient characteristics. By matching mechanism of a drug action with specific disease etiology, precision-medicine approaches are starting to turn the page in CVD trials.
Investigational drugs like mavacamten, developed by MyoKardia, offer new hope for patients with hypertrophic cardiomyopathy (HCM), an inherited and often lethal primary myocardial disorder without effective pharmacological options. Indeed, the striking positive results found in obstructive and non-obstructive HCM patients are expected to support a New Drug Application (NDA) filing, thus commencing a new promising chapter in the precision-medicine approach to CVD drug discovery.
For more information, or to register for this event, visit From Promise to Reality: MyoKardia and Medpace Talk Precision Medicine in Cardiovascular Disease.
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