General Scale-Up Strategies: Commonalities Between Mammalian And Microbial Processes, Upcoming Webinar Hosted by Xtalks

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In this free webinar, the featured speaker will discuss information required for a process transfer and how to scale, based on equipment design. Attendees will also learn common factors used for both mammalian and microbial processes.

Xtalks Life Science Webinars

Case studies will be presented to provide examples of an ideal scale-up scenario and a more creative solution to equipment adaptation problems as scale-up is not simply equations and multiplication but requires an understanding of how the equipment being used can impact the organism or protein

Scaling from bench to manufacturing for a mammalian or microbial process is very similar, despite the organisms having drastically different upstream growth profiles and requirements. Likewise, the downstream processes for both mammalian and microbial processes are very similar in general concepts with regards to protein purification strategies. In general, scale-up is considered a linear progression from the bench scale to the larger manufacturing scale, but not every parameter can scale linearly. Whether a process is able to scale linearly is dependent on process development robustness and compatible equipment design. The more robust the process development and the more similar the small-scale equipment to the large-scale equipment the more linear the process will scale. This webinar will focus on the equipment adaptations required for execution of upstream and downstream processes at the manufacturing scale considerations covered include adaptation to different types/designs of manufacturing equipment as well as linear vs non-linear scaling as result of equipment design differences between the small-scale and large-scale equipment.

This webinar will focus on common parameters used for organism growth and protein purification with a focus on mixing/agitation, gas flow, chromatography and filtration scaling. Case studies will be presented to provide examples of an ideal scale-up scenario and a more creative solution to equipment adaptation problems as scale-up is not simply equations and multiplication but requires an understanding of how the equipment being used can impact the organism or protein, i.e. as mixing/agitation rates may not be a linear multiplication because the number of impellers present on the shaft generate different mixing profiles. By the end of the webinar, participants should have a general understanding of the concepts and tools required to successfully scale a process from bench to manufacturing.

Join Stephanie Wickham Ph.D., Director of Manufacturing Sciences, Cytovance Biologics in a live webinar on Monday, August 31, 2020 at 12pm EDT (5pm BST/UK).

For more information or to register for this event, visit General Scale-Up Strategies: Commonalities Between Mammalian And Microbial Processes.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit http://xtalks.com
For information about hosting a webinar visit http://xtalks.com/why-host-a-webinar/

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Sydney Perelmutter
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