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Hepatic Artery Infusion (HAI) Therapy is Now Available Nationwide in More Than 65 Medical Centers


News provided by

Intera Oncology

Jan 30, 2024, 10:00 ET

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Intera Oncology
Intera Oncology

Over the last few years, an increasing body of clinical evidence and modernized therapy protocols have driven wider adoption of the treatment, leading to an increasing demand for more HAI programs. Since 2019, the number of cancer centers offering HAI therapy nationwide has grown more than 200%, making HAI available to more patients closer to their homes.

BOSTON, Jan. 30, 2024 /PRNewswire-PRWeb/ -- Intera Oncology today announced that Hepatic Artery Infusion (HAI), a liver-directed therapy for colorectal cancer that has spread to the liver, and intrahepatic cholangiocarcinoma (bile duct cancer), is now available at more than sixty-five medical centers across the United States, including nine of the top ten U.S. cancer centers.[1]

HAI therapy uses an implantable pump to deliver medicine directly to tumors within the liver. The treatment has been shown in clinical studies to reduce tumor size, improve disease control in the liver, and increase the likelihood that surgeons will be able to remove the tumors.[2,3] Studies have also demonstrated the potential of HAI therapy to prevent or delay recurrence after tumor removal and increase overall survival.[3,4,5,6] Intera Oncology is the manufacturer of the Intera 3000 Hepatic Artery Infusion Pump, the only Food and Drug Administration (FDA) approved pump for HAI therapy.

The growing availability of HAI therapy means more patients have access to this powerful treatment which provides up to 400 times higher drug concentration to the tumors in the liver compared to systemic chemotherapy, without adding systemic side effects.

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"The growing availability of HAI therapy means more patients have access to this powerful treatment which provides up to 400 times higher drug concentration to the tumors in the liver compared to systemic chemotherapy, without adding systemic side effects," Michael Gaisford, President and CEO of Intera Oncology, said. "Medical centers offering HAI are leaders in the field who want to offer advanced therapy options to their patients."

Historically, the availability of HAI therapy had been limited to a small number of top academic cancer centers, but over the last few years, more and more physicians and patients have learned about the benefits of HAI as an increasing body of clinical evidence and modernized therapy protocols have driven wider adoption of the treatment. This has led to an increasing demand for more HAI programs. Since 2019, the number of cancer centers offering HAI therapy nationwide has grown more than 200%, making HAI available to more patients closer to their homes.

Don Shippey understands the value of having more access to HAI therapy closer to home. In 2016, he was diagnosed with stage 4 colorectal cancer with liver metastases and told he had a 40% chance of surviving 12 months. Through his research, he learned about HAI therapy and traveled to New York for treatment. Today he has no evidence of disease.

"I was fortunate at the time to be able to travel from my home in Orlando to New York for treatment, but not everyone can do that," said Don. "Having more HAI centers around the country is a game changer. I speak with many patients who want to receive treatment closer to home."

Colorectal cancer is the third most common cancer in the U.S. affecting more than 150,000 people per year.[7] More than 50% of all people diagnosed with colorectal cancer will ultimately develop tumors in the liver, called colorectal liver metastases (CRLM).[8] Colorectal cancer is the leading cause of cancer-related death in men younger than 50 years of age.[7] HAI therapy combined with systemic chemotherapy has been shown to improve survival and reduce likelihood of recurrence.[3,4]

Intrahepatic cholangiocarcinoma (bile duct cancer) is a rare and devastating disease. The median survival when treated with systemic chemotherapy alone is 13 to 17 months with almost no survivors at 3 years. Adding HAI to systemic chemotherapy has been associated with an increased three-year survival rate of 39.5%.[6,9]

Intera Oncology provides newly established HAI programs with training and educational information on a range of HAI-related topics, including setup and management of HAI programs, and has a dedicated medical affairs team to help answer questions about HAI therapy.

ABOUT INTERA ONCOLOGY:

Intera Oncology® Inc. is a Boston-based medical device company founded in 2019 by two doctors with a singular vision for improving the survival of patients with colorectal cancer and intrahepatic cholangiocarcinoma by ensuring access to Hepatic Artery Infusion (HAI) therapy. Dedicated to helping patients live longer and better lives by changing the course of cancer with HAI therapy, Intera Oncology manufactures the only FDA-approved pump for HAI therapy – the Intera 3000 Hepatic Artery Infusion Pump. Today, the treatment is used in more than 65 cancer centers across the U.S., including nine of the U.S. News & World Report's top ten in the nation. Learn more at interaoncology.com and follow Intera on X, LinkedIn and Facebook.

Don's experience is unique to him, and individual results may vary. Talk to an HAI Therapy Specialist to see if this treatment may be right for you. See full safety information here.

The Intera 3000 Hepatic Artery Infusion Pump is indicated for the continuous arterial administration of Cerona Therapeutics Floxuridine for Injection, USP, heparinized saline, and glycerin. The approved labeling for Cerona Therapeutics Floxuridine for Injection, USP stipulates the indications, contraindications, and warnings for use of the drug in the pump. The Intera 3000 Hepatic Artery Infusion Pump is contraindicated for use in patients with extensive extrahepatic disease or limited hepatic function. Possible adverse events of the pump are those potential risks associated with any implanted drug delivery device and include: catheter thrombosis, bolus path occlusion, vessel thrombosis, pump dislodgement, seroma, or recurrent hematoma, infection, extravasation, catheter shear, dislodgement or leakage, migration, arterial pseudoaneurysm, arterial dissection, and extrahepatic perfusion.

Caution: Federal law (USA) restricts this device to sale by or on the order of a physician. Please review the full safety information at https://www.interaoncology.com/patients-caregivers/hai-therapy/safety-information.

1 U.S. News & World Report, Best Hospitals for Cancer.

2 Pak L, et al. J Surg Oncol. 2018;117(4):634–643.

3 Kemeny N, et al. N Engl J Med. 1999;341(27):2039-2048.

4 Dhir M, et al. Ann Surg Onc. 2017;24(1):150-158.

5 Groot Koerkamp B, et al. J Clin Oncol. 2017; 35(17): 1938–1944.

6 Holster J, et al. Ann Surg Oncol, 2022;29(9):5528–5538.

7 Siegel RL, et al. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254.

8 Zarour LR, et al. Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions. Cell Mol Gastroenterol Hepatol. 2017 Jan 20;3(2):163-173.

9 Cercek A, et al. JAMA Oncol. 2022;6(1):60-67.

Media Contact

Patricia Caballero, Intera, 1 973-348-5055, [email protected], interaoncology.com

SOURCE Intera

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