The FDA and other worldwide regulatory agencies are increasingly interested in biomarker investigations supporting efficacy and safety endpoints in submissions such as INDs and BLAs.
TORONTO (PRWEB) April 21, 2021
Unlike other antibody assays, immunohistochemistry (IHC) and immunofluorescence (IF) allow researchers and pathologists to visualize exactly where proteins are localized within tissues, providing cellular identity within the context of the tissue. The FDA and other worldwide regulatory agencies are increasingly interested in biomarker investigations supporting efficacy and safety endpoints in submissions such as INDs and BLAs.
IHC can be used to determine the lineage of neoplasms identified in routine H&E sections, distinguish apoptosis from necrosis and evaluate cell proliferation and tumor angiogenesis. In Tissue Cross-Reactivity Studies, IHC provides the ability to map the presence of targets across many tissues with the use of Tissue Micro Arrays (TMAs).
Research done properly utilizing IHC and IF by leveraging the right experience and expertise will ensure proper study design and marker selection, samples that provide clear data and pathology reports that accurately evaluate study results. Good quality and consistency of slide production reduces costs associated with extensive marker optimization work, reagents and equipment for small and diverse studies. This can ensure on-time research and decreased time to market.
Register for this webinar to learn about the benefits of including IHC and IF in pre-clinical and clinical research. Join Dr. Elizabeth Hutto, DVM, PhD, DACVP, Director of Investigative Pathology, StageBio; Dr. Matt Buccellato, DVM, PhD, DACVP, Senior Pathologist, StageBio; and Dr. Thomas Lemarchand, Director of Digital and Quantitative Pathology, StageBio, for the live webinar on Tuesday, May 11, 2021 at 1pm EDT (10am PDT).
For more information, or to register for this event, visit How Immunohistochemistry and Immunofluorescence Benefit Pre-Clinical and Clinical Research.
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