In this free webinar, learn about leveraging droplet microfluidics for evaluating single-cell heterogeneity using the Xdrop system. Attendees will explore how multiple cellular functionalities including cytotoxicity can be analyzed at the single-cell level. The featured speakers will also take participants through the integration of a microfluidics system with imaging cytometers and flow cytometers for detailed and high-throughput analyses.
TORONTO, June 11, 2024 /PRNewswire-PRWeb/ -- Traditional cell–cell interaction assays, including immune cell-mediated cytotoxicity assays, are typically performed in bulk, masking the true heterogeneity within cell populations. Samplix's Xdrop® revolutionizes cell–cell interaction assays by enabling analysis at the single-cell level, thereby revealing population heterogeneity.
Xdrop's single-cell encapsulation technology enables the functional analysis of single cells or single cell pairs as they are isolated into 100 pL double-emulsion droplets (DE50 droplets). Acting as micro-scale incubators, these droplets allow exchange of CO2 and O2 while retaining larger secreted molecules. Consequently, single-cell droplet encapsulation not only permits the analysis of single cells but also all secreted molecules.
Moreover, Xdrop® facilitates the simultaneous analysis of multiple cellular functionalities at the single-cell level. An example is the combined cell-killing and granzyme B secretion assay, which provides mechanistic insights into the cell-killing process.
In this webinar, the Xcyto®5 imaging cytometer (Chemometec) is used to simultaneously analyze cell killing and granzyme B secretion at the single-cell level. This approach provides detailed mechanistic insights into cell-mediated toxicity. By leveraging the high-resolution capabilities of the Xcyto®5 image cytometer in combination with Xdrop's single-cell encapsulation technology, the precise analyses of immune cell functional heterogeneity can be achieved.
Register for this webinar today to gain insights into how single-cell analysis can reveal intricate details of cell-mediated cytotoxicity and immune interaction.
Join Dr. Sidsel Alsing, Field Application Scientist, Samplix, for the live webinar on Tuesday, June 18, 2024, at 9:30am EDT (2:30pm BST/UK).
For more information, or to register for this event, visit Immune Cell-mediated Cytotoxicity: Single-cell Insights Using Droplets and Image Cytometry.
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