Immunophenotyping of T-cell Receptor and B-cell Receptor Clonotypes, Upcoming Webinar Hosted by Xtalks

TORONTO, June 16, 2021 /PRNewswire-PRWeb/ -- T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding the disease mechanisms and development of new therapeutics for infectious disease, auto-immunity and immuno-oncology applications. However, this potential could be greatly improved by combining information about receptor clonotypes with immunophenotypes of T and B cells. To facilitate these studies, we developed a novel technology for combined profiling of all human TCR and BCR variable regions and phenotypic characterization of immune cells in bulk and at the single-cell level in peripheral blood mononuclear cells (PBMC) and immune cell fraction samples.

The developed TCR/BCR Immunophenotyping method involves multiplex RT-PCR amplification and sequencing of complementarity-determining regions (CDR) of TCR and BCR genes and a set of the most informative T- and B-cell phenotyping genes. Bioinformatics analysis of NGS data allows for the profiling of TCR/BCR clonotypes, as well as identifying major immune cell subtypes and their activation status.

Register for this webinar to see data showing how combined TCR/BCR clonotype analysis combined with targeted expression profiling of immune cells can be applied for large-scale discovery of novel cell typing and activation biomarkers in several immune-response model systems. Preliminary studies demonstrate the assay has unparalleled throughput, sensitivity and improved cost-effectiveness for high-throughput immunity biomarker discovery applications.

Join Cellecta, Inc.'s President and Chief Scientific Officer Alex Chenchik, and Chief Operating Officer, Paul Diehl, Ph.D., for a live webinar on Thursday, July 8, 2021 at 11am EDT (4pm BST/UK).

For more information, or to register for this event, visit Immunophenotyping of T-cell Receptor and B-cell Receptor Clonotypes.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year, thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit http://xtalks.com
For information about hosting a webinar visit http://xtalks.com/why-host-a-webinar/

Media Contact

Ayesha Rashid, Xtalks, +1 (416) 977-6555 x 272, [email protected]

SOURCE Xtalks