Mureva Phototherapy and Siemens Healthineers today announced a U.S. co-marketing agreement to expand access to Mureva, the first FDA-authorized intraoral device for radiation-induced oral mucositis. The collaboration gives radiation oncology teams a practical way to deliver guideline-recommended photobiomodulation within existing workflows.
BRECKSVILLE, Ohio, Sept. 26, 2026 /PRNewswire-PRWeb/ -- Collaboration brings radiation oncology practices a practical way to deliver global guideline-recommended photobiomodulation to head and neck cancer patients across the U.S.
Mureva Phototherapy Inc. and Siemens Healthineers today announced a U.S. co-marketing agreement to expand awareness of and access to the Mureva treatment, the first FDA-authorized intraoral phototherapy device for radiation-induced oral mucositis (OM). Through the agreement, Siemens Healthineers will introduce radiation oncology practices to the Mureva treatment and connect them directly with Mureva to evaluate implementation.
The Mureva device received FDA De Novo authorization in 2025, establishing a new Class II classification for intraoral phototherapy devices, and previously received FDA Breakthrough Device Designation. The authorization was supported by a recently published, randomized, double-blind, sham-controlled pivotal trial in which Mureva significantly reduced the incidence of severe OM during radiation therapy compared with sham. No device-related adverse events were reported in the trial.1
OM is a common toxicity of radiation therapy for head and neck cancer, often associated with debilitating pain. When severe, it can compromise a patient's ability to eat and swallow, necessitate feeding-tube placement, disrupt cancer treatment, and diminish quality of life during treatment and recovery.
MASCC/ISOO global guidelines recommend intraoral photobiomodulation (PBM) for the prevention of OM in adults receiving radiation therapy for head and neck cancer. However, traditional approaches to delivering PBM can be resource- and time-intensive. Mureva is designed to make guideline-recommended PBM practical to incorporate into the radiation oncology workflow.
Mureva delivers a 10-minute treatment using two soft, flexible intraoral mouthpieces designed for daily use. The treatment can be implemented within existing ARIA® workflows to support efficient treatment scheduling, streamlined charge capture, and documentation without requiring a custom software interface.
"PBM has more than 20 years of evidence supporting its use in the prevention and management of OM, yet broad adoption has remained limited by the lack of a practical way to deliver it in routine care," said Vedang Kothari, Founder and President of Mureva. "What drives us is the opportunity to finally close that gap. With Siemens Healthineers' support, we can bring Mureva to more patients who need it."
"At Siemens Healthineers, we are committed to helping radiation oncology providers improve both clinical outcomes and the patient experience," said Mark Strausser, Head of Radiation Oncology Solutions Americas for Siemens Healthineers. "Oral mucositis remains one of the most challenging side effects faced by head and neck cancer patients undergoing radiation therapy. Through our collaboration with Mureva, we are helping bring awareness to an FDA-authorized solution designed to support guideline-recommended care while fitting seamlessly into existing clinical workflows. Together, we look forward to expanding access to innovative technologies that help providers deliver high-quality, patient-centered cancer care."
Under the agreement, the companies will coordinate customer education, sales enablement, digital promotion, and engagement at select industry events. Radiation oncology teams interested in learning more about Mureva can contact their local Siemens Healthineers representative or visit murevapt.com.
1 Hu K, Shah P, Nguyen MC, et al. Randomized, double-blind, sham-controlled trial of an intraoral photobiomodulation device for oral mucositis and associated complications due to radiotherapy for head and neck cancer. Support Care Cancer. 2026;34:696. doi:10.1007/s00520-026-10904-7
ARIA is a registered trademark of Varian Medical Systems, Inc.
Mureva Phototherapy Inc. is a privately held medical device company developing photobiomodulation solutions for patients receiving cancer treatment. Mureva's flagship device is the first FDA-authorized intraoral phototherapy device for radiation-induced oral mucositis and previously received FDA Breakthrough Device Designation. Its pivotal trial (NCT03972527) was presented at the 2025 American Society for Radiation Oncology (ASTRO) Annual Meeting and published in Supportive Care in Cancer in 2026.
Indication: Mureva OM is intended for use during radiation treatment to lower the severity of oral mucositis and associated complications with radiation-induced oral mucositis in adult patients receiving radiation to less than 75% of their oral cavity, with or without chemotherapy. Rx only.
For more information, visit murevapt.com.
Siemens Healthineers pioneers breakthroughs in healthcare. For everyone. Everywhere. Sustainably. The company is a global provider of healthcare equipment, solutions and services, with activities in more than 180 countries and direct representation in more than 70. The group comprises Siemens Healthineers AG, listed as SHL in Frankfurt, Germany, and its subsidiaries. As a leading medical technology company, Siemens Healthineers is committed to improving access to healthcare for underserved communities worldwide and is striving to overcome the most threatening diseases. The company is principally active in the areas of imaging, diagnostics, cancer care and minimally invasive therapies, augmented by digital technology and artificial intelligence. In fiscal 2025, which ended on September 30, 2025, Siemens Healthineers had approximately 74,000 employees worldwide and generated revenue of around €23.4 billion. Further information is available at siemens-healthineers.com.
Media Contacts:
Vedang Kothari, Mureva, 408-712-1734, [email protected]
Michelle Joiner, G3 Medical Marketing, 678-938-4163, [email protected]
Media Contact
Michelle Joiner, G3 Medical Marketing, 1 6789384163, [email protected], https://murevapt.com/
SOURCE Mureva Phototherapy Inc
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