Purification of Oligonucleotides Using Anion-Exchange Chromatography, Upcoming Webinar Hosted by Xtalks
In this free webinar, the featured speaker will discuss common purification strategies for oligonucleotides, including the principles for separation of oligonucleotides based on their negatively-charged phosphate backbones, as well as important parameters in the optimization process and how they may differ for different molecules. Learn how to optimize yield and purity and the importance of choosing a good resin with optimized properties in regard to bead size and pore size.
TORONTO, Ontario, Oct. 26, 2021 /PRNewswire-PRWeb/ -- Therapeutic RNA and DNA molecules have a stringent requirement for purity, often achieved using high-resolution anion-exchange chromatography which separates full-length sequences from incomplete or erroneous sequences.
In this webinar, the featured speaker will discuss the common purification strategies for oligonucleotides. Three case studies will be presented on the effects of residence time, temperature and type of resin on loading capacities for a 20-mer DNA, a 45 nt-long RNA and a pegylated RNA. The expert speaker will also discuss an analysis of the correlation between purity and yield using optimized conditions.
Key topics of discussion will include:
- The principles for separation of oligonucleotides based on their negatively-charged phosphate backbones
- Which parameters are important in the optimization process and how they may differ for different molecules
- How to optimize yield and purity
- The importance of choosing a good resin with optimized properties
Join Cecilia Unoson, Manager – Applications, Bio-Works, in a live webinar on Thursday, November 11, 2021 at 10am EST (3pm GMT/UK) to learn about best practices for using anion-exchange chromatography to purify therapeutic oligonucleotides.
For more information, or to register for this event, visit Purification of Oligonucleotides Using Anion-Exchange Chromatography.
ABOUT XTALKS
Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year, thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.
To learn more about Xtalks visit http://xtalks.com
For information about hosting a webinar visit http://xtalks.com/why-host-a-webinar/
Media Contact
Ayesha Rashid, Xtalks, +1 (416) 977-6555 x 272, [email protected]
SOURCE Xtalks

Share this article