Purification of Oligonucleotides Using Anion-Exchange Chromatography, Upcoming Webinar Hosted by Xtalks

In this free webinar, the featured speaker will discuss common purification strategies for oligonucleotides, including the principles for separation of oligonucleotides based on their negatively-charged phosphate backbones, as well as important parameters in the optimization process and how they may differ for different molecules. Learn how to optimize yield and purity and the importance of choosing a good resin with optimized properties in regard to bead size and pore size.

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Oct 26, 2021, 08:30 ET


TORONTO, Ontario, Oct. 26, 2021 /PRNewswire-PRWeb/ -- Therapeutic RNA and DNA molecules have a stringent requirement for purity, often achieved using high-resolution anion-exchange chromatography which separates full-length sequences from incomplete or erroneous sequences.

In this webinar, the featured speaker will discuss the common purification strategies for oligonucleotides. Three case studies will be presented on the effects of residence time, temperature and type of resin on loading capacities for a 20-mer DNA, a 45 nt-long RNA and a pegylated RNA. The expert speaker will also discuss an analysis of the correlation between purity and yield using optimized conditions.

Key topics of discussion will include:

  • The principles for separation of oligonucleotides based on their negatively-charged phosphate backbones
  • Which parameters are important in the optimization process and how they may differ for different molecules
  • How to optimize yield and purity
  • The importance of choosing a good resin with optimized properties

Join Cecilia Unoson, Manager – Applications, Bio-Works, in a live webinar on Thursday, November 11, 2021 at 10am EST (3pm GMT/UK) to learn about best practices for using anion-exchange chromatography to purify therapeutic oligonucleotides.

For more information, or to register for this event, visit Purification of Oligonucleotides Using Anion-Exchange Chromatography.

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