This methodology should be embraced as a way to not only save thousands of fish but also offers significant financial savings to those needing the study.
TORONTO (PRWEB) September 29, 2020
Fish bioconcentration or biomagnification studies are carried out to determine whether substances have the potential to bioaccumulate and bio-magnify throughout different trophic levels. There are increasing requirements to conduct these studies on a broad variety of industrial chemicals, pharmaceuticals and crop protection products across the globe, resulting in the use of significant numbers of fish. The preferred method of testing requires three doses of chemical (including a control) with up to 100 fish per dose. However, following the revision to the OECD Test Guideline (OECD 305: 2012) there is now the option to test on one concentration and the control only, providing there is scientific justification. This has the potential to decrease the numbers of fish used in these tests by one third (100 fish per study).
Here we present evidence obtained through conducting numerous bioaccumulation studies over the years, on multiple different chemicals, that the one-dose approach is an appropriate alternative to the full study. We demonstrate the applicability of the one-dose method in both aqueous exposure studies and the dietary exposure testing route. The studies conducted have all of the bio-kinetic data required and still show statistical robustness. This methodology should be embraced as a way to not only save thousands of fish but also offers significant financial savings to those needing the study.
Join Dr. Emma Danby, Principal Scientist, Aquatic Ecotoxicology, Covance and Lindsay Knight, Scientific Project Manager, Metabolism, Covance in a live webinar on Thursday, October 15, 2020 at 9am EDT (2pm BST/UK).
For more information or to register for this event, visit Reducing Fish Numbers in BCF and BMF Studies by Applying the One Dose Approach.
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