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Reliability of Liver Biopsies in NASH Clinical Studies: What is Known So Far? What's Next? Upcoming Webinar Hosted by Xtalks

In this free webinar, the featured speakers will discuss the available data assessing reproducibility of liver biopsy reading in NASH and explain how to leverage lessons learned from other liver indications. Attendees will learn about potential mitigation strategies to minimize the inter- and intra-subject variability, how training standards can be implemented and statistical strategies to maximize power and minimize the impact of this variability.


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Xtalks

Oct 23, 2020, 08:30 ET

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TORONTO, Oct. 23, 2020 /PRNewswire-PRWeb/ -- Liver biopsy (LB) sample evaluation is an essential part of clinical studies in non-alcoholic steatohepatitis (NASH). However, LB remains a vastly controversial and debated subject. Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma. Therefore, sampling error in liver biopsy can result in substantial misdiagnosis and staging inaccuracies. Additionally, though previous data suggested substantial or moderate concordance for some key histological NASH features (e.g fibrosis, ballooning degeneration), poor concordance in these components were reported in a recent trial.

The panel will present available data assessing reproducibility of liver biopsy reading in NASH, methodological aspects in the interpretation of data and potential limitations, discuss how to leverage lessons learned from other liver indications, brainstorm about potential central reading options and evaluate potential mitigation strategies to minimize the inter- and intra-subject variability.

Sampling error in liver biopsy can result in substantial misdiagnosis and staging inaccuracies.

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Join Claudia Filozof, MD, PhD, Vice President, Liver Therapeutic Area Head, Global Clinical Development, Covance, Troy Johnson, MS, Statistical Fellow, Biostatistics, Covance, Pierre Bedossa, Professor of Pathology, Liverpat and Arun Sanyal, MD, Professor of Medicine at Virginia Commonwealth University (VCU) School of Medicine, Richmond, VA in a live webinar on Monday, November 9, 2020 at 11am EST (4pm GMT/UK).

For more information or to register for this event, visit Reliability of Liver Biopsies in NASH Clinical Studies: What is Known So Far? What's Next?

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit http://xtalks.com
For information about hosting a webinar visit http://xtalks.com/why-host-a-webinar/

SOURCE Xtalks

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