Sampling error in liver biopsy can result in substantial misdiagnosis and staging inaccuracies.
TORONTO (PRWEB) October 23, 2020
Liver biopsy (LB) sample evaluation is an essential part of clinical studies in non-alcoholic steatohepatitis (NASH). However, LB remains a vastly controversial and debated subject. Histologic lesions of NASH are unevenly distributed throughout the liver parenchyma. Therefore, sampling error in liver biopsy can result in substantial misdiagnosis and staging inaccuracies. Additionally, though previous data suggested substantial or moderate concordance for some key histological NASH features (e.g fibrosis, ballooning degeneration), poor concordance in these components were reported in a recent trial.
The panel will present available data assessing reproducibility of liver biopsy reading in NASH, methodological aspects in the interpretation of data and potential limitations, discuss how to leverage lessons learned from other liver indications, brainstorm about potential central reading options and evaluate potential mitigation strategies to minimize the inter- and intra-subject variability.
Join Claudia Filozof, MD, PhD, Vice President, Liver Therapeutic Area Head, Global Clinical Development, Covance, Troy Johnson, MS, Statistical Fellow, Biostatistics, Covance, Pierre Bedossa, Professor of Pathology, Liverpat and Arun Sanyal, MD, Professor of Medicine at Virginia Commonwealth University (VCU) School of Medicine, Richmond, VA in a live webinar on Monday, November 9, 2020 at 11am EST (4pm GMT/UK).
For more information or to register for this event, visit Reliability of Liver Biopsies in NASH Clinical Studies: What is Known So Far? What’s Next?
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