Biotherapeutic development is a critical component of drug manufacturer pipelines as the pharmaceutical industry moves toward more targeted therapies.
TORONTO (PRWEB) November 19, 2019
Join Brian Rivera, Senior Global Product Manager of Biologics at Phenomenex Inc. in a live webinar on Wednesday, December 11, 2019 at 11am EST (4pm GMT/UK) to hear about the basics of size exclusion chromatography, aggregation of protein-based therapeutics and best practices for selecting the right columns for your applications.
Biotherapeutic development is a critical component of drug manufacturer pipelines as the pharmaceutical industry moves toward more targeted therapies. Liquid chromatography plays an important role in biotherapeutic development as it assists in identity and purity assessments. Aggregation of protein-based therapeutics is the most common critical quality attribute (CQA) analyzed through the drug development process. Because aggregation is so important, there is an abundance of size exclusion chromatography (SEC) options on the market that can determine levels of aggregation of a protein biotherapeutic. Because each SEC column possesses unique properties, methods must be adjusted to match the column choice.
This webinar will cover:
- An overview of biotherapeutic aggregation and size exclusion chromatography
- The role of chromatography hardware in aggregate analysis
- How method parameters such as pH, flow-rate and salt concentration influence SEC
- Adaptation of SEC methods to mass spectrometry through native mass spectrometry (MS) method development
For more information or to register for this event, visit Size Exclusion Chromatography: How to Select an SEC Column and Optimize a Method.
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