Supporting the Development of Protein Drugs By LC-MS-Based Bioanalysis, Upcoming Webinar Hosted by Xtalks

Share Article

In this free webinar, the featured speaker will discuss the recent technical advances in protein LC-MS and how the different technical approaches compare from an analytical point of view. Attendees will learn about the relevance of the complex structure and behavior of macromolecules for the meaning of a concentration result.

Xtalks Logo

Xtalks Life Science Webinars

Because of its fundamentally different analytical principles, LC-MS can provide qualitative and quantitative information about proteins in biological samples that is complementary to LBA results.

Join Nico van de Merbel, Senior Director, Bioanalytical Science, PRA Health Sciences in a live webinar on Tuesday, October 6, 2020 at 11am EDT (4pm BST/UK).

Over the past decade, the use of LC-MS for the quantitative determination of proteins in biological samples has increased considerably, and this technique can now be considered an established bioanalytical platform for the quantification of macromolecular drugs and biomarkers, next to the traditional ligand-binding assays (LBA’s). Because of its fundamentally different analytical principles, LC-MS can provide qualitative and quantitative information about proteins in biological samples that is complementary to LBA results.

This webinar will give an overview of recent developments in the field of protein LC-MS, as applied to support the (pre)clinical development of macromolecular pharmaceuticals. Attention will be paid to technical developments with regard to sample handling, chromatography and MS detection of both digested and intact proteins, and the relative merits of different approaches, such as immunocapture and generic extraction, or unit- and high-resolution MS, will be compared and discussed.

In addition, advances in understanding the actual meaning of the results will be highlighted. Because of the complex structure of proteins and their often neglected in vivo behavior, quite different concentration results may be obtained when different analytical techniques are applied, and a proper understanding of what a result represents is essential. The effect of protein–protein interactions, biotransformation and the occurrence of protein isoforms on the analytical result will be addressed. Practical examples from both preclinical and clinical analysis, for biopharmaceuticals and biomarkers in different biological matrices, will be used as illustrations.

For more information or to register for this event, visit Supporting the Development of Protein Drugs By LC-MS-Based Bioanalysis.

ABOUT XTALKS

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit http://xtalks.com
For information about hosting a webinar visit http://xtalks.com/why-host-a-webinar/

Share article on social media or email:

View article via:

Pdf Print

Contact Author

Sydney Perelmutter
Xtalks
+1 (416) 977-6555 x 352
Email >
Visit website