This webinar will focus on our efforts with PROTACs in the areas of inflammation and cancer.
TORONTO (PRWEB) October 19, 2020
Proteolysis targeting chimera or PROTAC is a novel drug discovery strategy that has brought a paradigm shift and significant opportunity to transform the way medicinal chemistry and drug discovery programs are currently planned and executed. With sub-stoichiometric catalytic mode of action, PROTACs reduce the need for target occupancy as necessitated with traditional small molecule inhibitors. PROTACs hold great promise to target highly mutable kinases and signalling proteins, which promote cancer and drug resistance (e.g., KRAS, BRAF and EGFR).
This webinar will focus on our efforts with PROTACs in the areas of inflammation and cancer. Specifically, we will discuss challenges and opportunities for developing PROTACs in the areas of autoimmune and inflammatory diseases driven by IL-1R/TLR1 signaling and inflammasome activation and in potentially undruggable epigenetic pathways that involve bromodomain proteins, histone acetyltransferases and deacetylases.
The webinar will also address some of the DMPK challenges in developing PROTACs and strategies and optimizations that might aid the development of orally bioavailable PROTAC candidates.
Join Amar Thyagarajan, Ph.D., Global Strategy Head and Head of North America BD (Biology Solutions), GVK Biosciences and Aragen Biosciences and Venkatesh Babu Jayaraman, Principal Scientific Manager, GVK Biosciences in a live webinar on Friday, October 30, 2020 at 11am EDT (3pm GMT/UK).
For more information or to register for this event, visit Targeted Protein Degradation in Inflammation and Cancer Therapy.
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