Accessibility Statement Skip Navigation
  • Why PRWeb
  • How It Works
  • Who Uses It
  • Pricing
  • Login
  • GDPR
  • Create a Free Account
Return to PRWeb homepage
  • News
  • Resources
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All News Releases
      • Multimedia Gallery

      • All Multimedia
      • All Photos
      • All Videos
  • Business & Money
      • Auto & Transportation

      • Aerospace, Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads and Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking and Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers and Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalization
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls and Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil and Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defense
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation and Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking and Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers and Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines and Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics and Personal Care
      • Fashion
      • Food & Beverages
      • Furniture and Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewelry
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks and Tourist Attractions
      • Gambling & Casinos
      • Hotels and Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Advocacy Group Opinion
      • Animal Welfare
      • Congressional & Presidential Campaigns
      • Corporate Social Responsibility
      • Domestic Policy
      • Economic News, Trends, Analysis
      • Education
      • Environmental
      • European Government
      • FDA Approval
      • Federal and State Legislation
      • Federal Executive Branch & Agency
      • Foreign Policy & International Affairs
      • Homeland Security
      • Labor & Union
      • Legal Issues
      • Natural Disasters
      • Not For Profit
      • Patent Law
      • Public Safety
      • Trade Policy
      • U.S. State Policy
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Hamburger menu
  • Cision PRWeb provides efficient communication tools to continuously engage with target audiences across multiple online channels
  • Create a Free Account
    • ALL CONTACT INFO
    • Contact Us


      11AM ET Sunday – 8PM ET Friday

  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • News in Focus
    • Browse All News
    • Multimedia Gallery
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR
  • Send a Release
  • Sign up
  • Log in
  • Resources
  • RSS
  • GDPR

The Difference a Diagnosis Makes: How Understanding Fear of Harm Syndrome May Help Save Your Child

FOH includes a physical symptom, the inability to self-regulate internal body temperature, the challenge now is to raise awareness of the FOH diagnosis in the broader world, and to have the use of intranasal ketamine adopted as a standard clinical practice for treatment of this condition. JBRF is taking steps to make that happen.


News provided by

JBRF

Oct 11, 2018, 15:00 ET

Share this article

Share toX

Share this article

Share toX


WHITE PLAINS, N.Y., Oct. 11, 2018 /PRNewswire-PRWeb/ -- Alice* is artistic, intelligent and on her third school placement. Her parents remember that she was always very hot as a baby. Growing up she would constantly kick off the bed covers, often waking up in a pool of sweat with terrifying nightmares that no one could explain. She was often afraid to go to sleep. She would worry about everything, howled when she was separated from her parents and often demanded to sleep in their bed.

Alice could never seem to wake up in the morning. She would get angry about getting up, and always had dark circles under her eyes. Criticism crushed her. She complained constantly of being bored, and couldn't handle delays. It was hard for her to keep friends because of her bossiness and tendency to be argumentative. She'd erupt in a rage when her parents tried to set limits. And recently, she'd taken a dark turn, brooding, cursing, getting lost in gory graphic novels.

“Juvenile bipolar disorder and FOH are major social as well as medical issues,” says Dr. Papolos.

Post this

She's seen several doctors and counselors. They diagnosed ADHD, depression and an alphabet soup of other labels (ODD, OCD, DMDD) that almost but didn't quite fit. She's been given a host of stimulants like Ritalin and Adderal, as well as antidepressents, but nothing seemed to do much good. And according to Dr. Demitri Papolos, Director of Research for the Juvenile Bipolar Research Foundation (JBRF), those drugs probably won't help, and may even cause more irritability, agitation and mood cycling.

That's because Alice, and thousands more children, likely suffers from a specific sub-type of juvenile bipolar disorder. The clues from her history indicate Alice may have Fear of Harm (FOH) syndrome, which occurs in a subgroup of children with bipolar disorder. It's a relatively new diagnosis, but it's a critical one, because research sponsored by JBRF has not only discovered this syndrome, it's determined there is an effective treatment for it, too.

"Juvenile bipolar disorder and FOH are major social as well as medical issues," says Dr. Papolos. A study that examined the clinical profiles of over 5000 youth diagnosed with bipolar disorder suggests that fully one-third have FOH. It's estimated that hundreds of thousands of children may suffer from FOH, and that it may be rampant in juvenile justice cases. "These children are usually misdiagnosed, and the typical drug treatments used can make them more aggressive," explains Dr. Papolos.

Breakthrough Biomarker

JBRF has been working to change the way juvenile bipolar disorder is diagnosed and treated since 1999. Through the use of big-data analytics, over the course of eight years researchers identified a sub-set within the population of patients diagnosed with juvenile bipolar disorder. This sub-set is defined by symptoms that include extreme anxiety and fear of harm to self or others, or what is termed "Fear of Harm" (FOH) syndrome.

What is unique about FOH is that it includes, for the first time, a physical symptom, or biomarker, for a mental illness. Among other symptoms, these children feel hot much of the time, a sign that their bodies are not able to self-regulate their internal temperature. This thermoregulatory disturbance plays a significant role in the development of symptoms of their illness.

"The thermoregulation problem impacts many functions in the body, including sleep," explains Dr. Papolos. "Kids with FOH have problems with the dissipation of heat, so they have challenges getting to sleep and arising. The smooth transitions from REM to non-REM sleep are also affected, and they often have frequent vivid nightmares very early on in their development, even at pre-verbal stages. They have a fluidity between waking and dream states and may see frightening and morbid images – REM intrusions – as soon as they close their eyes. Their brains may experience this imagery as if it's real, so fear sensitivity develops very early and they may develop symptoms akin to PTSD where even neutral experiences can trigger a fight or flight response. This state of threat can lead to other behavioral issues."

A Breath of Hope

Once Dr. Papolos and the JBRF sponsored researchers discovered the FOH syndrome, they set about looking for treatments that could be used to mitigate it. One drug, ketamine, was known to affect both fear sensitivity and thermoregulation. Originally developed as an anesthetic, ketamine is used by dentists for children, and has recently shown promise in treating people who come into emergency rooms with suicidal thoughts. Could ketamine help FOH kids?

The team determined that ketamine can indeed be used via intranasal administration to mitigate FOH symptoms and manage bipolar disorder. Ketamine is known to influence the regulation of body temperature and to reduce the intensity of conditioned fear. They embarked on research to evaluate if intranasal ketamine could be effective and safe for long term use. Their findings offer hope for thousands.

For FOH patients, the administration of intranasal ketamine combined with therapeutic levels of lithium salts or another mood stabilizer results in a substantial reduction in measures of mania, fear of harm and aggression. A rapid, substantial therapeutic response showed significant improvement in patients' mood, anxiety and behavioral symptoms. And in what proved to be the clearest marker of a response to intranasal ketamine treatment, the patients' thermoregulation improved significantly.

JBRF sponsored researchers published their initial findings in the Journal of Affective Disorders in 2012. They also published a follow up study in the same journal in 2017, which documented treatment results over a span of six years. The bottom line? For patients who fit the FOH diagnosis, intranasal ketamine treatments can change their lives.

The challenge now is to raise awareness of the FOH diagnosis in the broader world, and to have the use of intranasal ketamine adopted as a standard clinical practice for treatment of this condition. JBRF is taking steps to make that happen, offering information on their website for families and medical professionals, and launching a series of informal presentations aimed at increasing awareness of FOH and ketamine treatment. Training for mental health professionals and inclusion of the FOH diagnosis in the DSM are future goals.

"For children and adolescents with FOH, accurate diagnosis of FOH and treatment with a mood stabilizer and intranasal ketamine can be transformational," says Dr. Papolos. "I believe there are many, many more children out there who can benefit."

For more on FOH and juvenile bipolar disorder, the JBRF website has helpful information.
For in depth information on FOH: https://www.jbrf.org/what-is-fear-of-harm/
For an online diagnostic questionnaire: https://www.jbrf.org/the-child-bipolar-questionnaire-for-families-use/
For a list of research and useful tools: https://www.jbrf.org/

*This patient profile is drawn from real examples, but is a fictional conflation to protect privacy.

SOURCE JBRF

Related Links

https://www.jbrf.org

Modal title

The Difference a Diagnosis Makes
View PDF
The Difference a Diagnosis Makes
JBRF Logo
JBRF Logo
The Difference a Diagnosis Makes JBRF Logo

Contact PRWeb

  • 11AM ET Sunday – 8PM ET Friday
  • Contact Us

About PRWeb

  • About PRWeb
  • Partners
  • Partnership Programs
  • Editorial Guidelines
  • Resources

Why PRWeb

  • Why PRWeb
  • How It Works
  • Who Uses It
  • Pricing

Accounts

  • Create a Free Account
  • Log in
  • Contact Us

Do not sell or share my personal information:

  • Submit via [email protected] 
  • Call Privacy toll-free: 877-297-8921

Contact Cision

Products

About

My Services
  • All News Releases
  • Online Member Center
  • ProfNet
Cision Distribution Helpline
888-776-0942
  • Legal
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 Cision US Inc.