The Evidence Behind Platelet-Rich Fibrin Use in Dental Procedures

Share Article

In a study published in the Journal of Oral Implantology, researchers conduct a 15 year retrospective study of a new method of obtaining stable tissue and bone regeneration called platelet-rich fibrin (PRF). Given their findings, they believe there needs to be a standardization of PRF protocols.

Journal of Oral Implantology 44.6 Cover

Journal of Oral Implantology 44.6

Journal of Oral Implantology – Soft tissue and bone regeneration are an essential aspect of maintaining long-term dental treatments. Recently, a new method called platelet-rich fibrin (PRF) has been particularly helpful in obtaining the level of stable tissue and bone regeneration necessary for successful oral and maxillofacial surgeries. PRF is a one-step method to obtain the platelet concentrates, or blood derivatives, that are needed to aid in the regeneration of soft tissue and bone, thereby creating a stable environment to perform oral procedures, such as implants. But how much scientific evidence is there to support this new technique?

Researchers from the University Hospital Frankfurt Goethe University, Nova Southeastern University, University Medical Center (Germany), Universitätsklinikum Düsseldorf (Germany) and Pain Therapy Center (France) recently published a 15-year retrospective study in the Journal of Oral Implantology that evaluates the use of this novel method.

In their analysis, the researchers examined 72 articles that met the following criteria: the term “platelet rich fibrin (PRF)” was in the title, relationship only to clinical applications in dentistry and different application fields, human studies and English-language publications. These articles comprised 21 randomized clinical trials, 21 nonrandomized controlled prospective studies, 13 quasi-experimental studies and 17 case-control studies. Overall, 1,861 patients were involved in PRF studies and the highest application of PRF was used in the maxillofacial field of dentistry (40%), followed by periodontology (36.1%), implantology (13.8%), endodontics (8.3%) and orthodontics (1.3%).

The researchers determined that more than 70% of patients were involved in highly evidence-based studies. They found 38 studies showing PRF as a beneficial tool to enhance bone and soft tissue regeneration and a further 17 that reported PRF as the sole biomaterial used. Additionally, in nine studies, PRF showed significant improvement in pocket depth and clinical attachment level with regard to periodontology. Seven articles reported significantly enhanced new bone formation during socket preservation and ridge augmentation. Finally, regarding treatment with PRF for medication-related osteonecrosis of the jaw, 96 of 101 patients healed uneventfully. Of the 72 articles examined, only one showed results favoring the control group versus the PRF-treated group.

Given the level of success shown from using PRF as a method of soft tissue and bone regeneration, the researchers believe that a standardization of PRF protocols should be put into place in order to create additional studies with higher levels of scientific evidence. The clinical community will benefit from such studies to promote PRF in tissue regeneration moving forward.

Full text of the article, “Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High Is the Level of Scientific Evidence?” Journal of Oral Implantology, Vol. 44, No. 6, 2018, is available at

About the Journal of Oral Implantology
The Journal of Oral Implantology is the official publication of the American Academy of Implant Dentistry and of the American Academy of Implant Prosthodontics. It is dedicated to providing valuable information to general dentists, oral surgeons, prosthodontists, periodontists, scientists, clinicians, laboratory owners and technicians, manufacturers, and educators. The JOI distinguishes itself as the first and oldest journal in the world devoted exclusively to implant dentistry. For more information about the journal or society, please visit

Share article on social media or email:

View article via:

Pdf Print

Contact Author

Dominique Scanlan
Allen Press
+1 (785) 865-9226
Email >
Visit website