The data suggest that tissue-engineered models fabricated using hPSC-derived ventricular cardiac cells cultured as anisotropic sheets and 3D tissue strips are key in understanding the pathogenesis of FRDA cardiomyopathy, and are suitable for pharmaceutical testing.
Toronto, ON (PRWEB) October 17, 2019
Tissue-engineered human in vitro models represent an important paradigm shift in the study of Friedreich’s ataxia (FRDA) and other genetic cardiomyopathies including Barth syndrome, left ventricular noncompaction, hypoplastic left heart syndrome, familial hypertrophic cardiomyopathy and others. These human-relevant models hold the promise of revolutionizing the manner in which drugs are currently discovered and developed.
Join Bernard Fermini, Chief Research & Development Officer at Novoheart in a live webinar on Wednesday, October 30, 2019 at 12pm EDT to learn about the use of human pluripotent stem cells (hPSCs) and tissue-engineered models to study FRDA cardiomyopathy. Human ventricular cardiac anisotropic sheets (hvCAS) and tissue strips (hvCTS) were generated from human embryonic stem cell (hESC) and induced pluripotent stem cell (hiPSC)-derived ventricular cardiomyocytes (VCMs) for modelling FRDA’s electrophysiological and contractile defects, respectively.
The findings show that human-based FRDA in vitro models provide a biomimetic platform suitable to facilitate the study of the disease. The data suggest that tissue-engineered models fabricated using hPSC-derived ventricular cardiac cells cultured as anisotropic sheets and 3D tissue strips are key in understanding the pathogenesis of FRDA cardiomyopathy, and are suitable for pharmaceutical testing.
For more information or to register for this free webinar, visit Tissue-Engineered Human Models of Cardiac Disease: A Case Study of Friedreich’s Ataxia (FRDA).
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