Tosoh Bioscience Introduces LenS3™ Multi-Angle Light Scattering Detector at Pittcon 2019

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A New Paradigm in Light Scattering Technology

LenS3 Multi-Angle Light Scattering detector

LenS3 Multi-Angle Light Scattering detector

Featuring a patent pending cell geometry, a lower wavelength laser, an improved normalization process and a new method for utilizing the angular dependence, the determination of radius of gyration of macromolecules below 10 nm, is now possible for the first time in history!

Tosoh Bioscience LLC is proud to announce the introduction of its LenS3 Multi-Angle Light Scattering (MALS) detector, offering a revolutionary approach for the measurement of molecular weight (MW) and radius of gyration (Rg) of synthetic polymers, polysaccharides, proteins, and biopolymers. A novel optical design, a unique cell-block assembly, and a new calculation methodology make the LenS3 MALS detector the first groundbreaking innovation in the light scattering technology arena in decades!

Featuring a patent pending cell geometry and a lower wavelength laser (at 514 nm), the LenS3 MALS detector allows direct measurement of molecular weight and provides best-in-class sensitivity. In addition, with an improved normalization process and a new method for utilizing the angular dependence, the determination of radius of gyration of smaller macromolecules below 10 nm in gyration size, Rg, is now possible for the first time in history!

Light scattering of macromolecules in solution has seen increasing interest over the past decades from scientists studying polymers and proteins. HPLC-SEC systems, coupled with online light scattering detection, has proven to be a powerful tool for measuring absolute molecular weight and the gyration size of the macromolecules. The technique is also essential in identification and quantification of aggregation levels in proteins and monoclonal antibodies and in studying their conformation in various solution conditions.

The LenS3 MALS detector is driven by SECview™ software, capable of GPC system/hardware control, multi-channel data acquisition, data processing and analysis. Totally focused around enhancing the user-interface experience, SECview is a welcoming fresh perspective that streamlines the complex calculations required by the advanced detectors and is the only GPC/SEC data processing module today that performs analysis of sample-of-interest using multiple calibration methods simultaneously.

The LenS3 MALS detector is now available for sale in the Americas from Tosoh Bioscience LLC.

TOSOH BIOSCIENCE LLC
Tosoh Bioscience LLC provides liquid chromatography products to laboratories and manufacturing plants in the Americas. While the majority of our customers work in biotechnology and pharmaceutical companies, our HPLC columns and systems are essential tools for sample analysis in most industries. Our all-in-one dedicated GPC system, the EcoSEC GPC System, is predominantly used in the chemical and polymer industries while our EcoSEC High Temperature GPC System is ideal for the polyolefin and oil industries. In the field of biotechnology, our preparative chromatography resins play a critical role in the purification of proteins and nucleic acids for medical purposes.

The company is a subsidiary of Tosoh Corporation in Japan, the parent of the Tosoh Group, which comprises over 100 companies worldwide and a multiethnic workforce of over 12,000 people and generated sales of ¥822.9 billion (US $7.4 billion at the average rate of ¥100.85 to the US dollar) in fiscal 2018, ended March 31, 2018.

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Cara Tomasek
Tosoh Bioscience LLC
+1 484-805-1219 Ext: 0
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since: 07/2012
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