In this free webinar, learn about trends in cardiac toxicity in oncology clinical trials and learn how core laboratories are standardizing data collection techniques.
TORONTO (PRWEB) May 13, 2019
- Trends in cardio-oncology
- Perspectives from regulatory, academia and industry
- Recommendations regarding the prediction, avoidance and detection of CV safety events in oncologic drug development
- Reducing variability in electrocardiogram/echocardiogram data acquisition and analysis
In recent years, the development of clinical trials using targeted agents has been stimulated by the identification of pathways involved in carcinogenesis, metastasis and drug resistance and by the emergence of molecular analysis of tumors. These targeted agents are initially investigated as single agents in phase I clinical trials, and, if well tolerated, in phase II and III studies. However, some targeted agents can cause arrhythmia, hypertension, ischemia or left ventricular (LV) dysfunction. Because determining the maximum tolerated dose and dose-limiting toxicity are primary endpoints of phase I clinical trials, many useful targeted agents that cause excess cardiac toxicity might not proceed to phase II trials. Therefore, cardiac risk factors should be taken into account in the selection and management of patients with cancer who are enrolled in phase I clinical trials.
Centralizing electrocardiograms and echocardiograms have become the industry standard for collecting and analyzing these data. Core laboratories act to reduce variability by standardizing collection techniques and reading paradigms. The reduction in variability can result in fewer false positive readings for the sponsor.
For more information or to register for this event, visit Trends in Cardio-Oncology & the Implications for Detecting Cardiac Toxicity in Clinical Trials.
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