A new case report published in the Journal of Oral Implantology highlights the successful treatment of a severe peri-implantitis case using xenogenic bone substitutes and collagen matrix. Researchers from Shahid Beheshti University of Medical Sciences in Tehran treated a 64-year-old woman suffering from inflammation and bone loss around a dental implant. The procedure involved deep cleaning, titanium mesh placement, and application of xenogenic materials, resulting in complete recovery and bone regeneration sustained over four years. The study's authors, Drs. Mahdi Kadkhoazadeh and Ali Azadi, emphasize the potential of xenogenic materials as an effective, long-term management option for peri-implantitis.
GLEN ALLEN, Va., Nov. 24, 2025 /PRNewswire-PRWeb/ -- Xenographic Materials Show Positive Outcomes for Peri-Implantitis Treatment
Journal of Oral Implantology – As dental implants become more commonplace in general dentistry, practitioners are increasingly encountering complications related to peri-implantitis. Symptoms of peri-implantitis include progressive inflammation and bone loss around the dental implant, which puts the efficacy of the implant at risk. Currently, there are no universally accepted clinical protocols in place for managing peri-implantitis; however, research in the field has been expanding since 2021.
Researchers from Shahid Beheshti University of Medical Sciences in Tehran, Iran, recently published a case report in the Journal of Oral Implantology outlining the treatment of an individual with peri-implantitis around a lower molar implant site. The treatment plan included the use of xenographic materials (bone substitute), and collagen matrix. The researchers also performed a series of deep cleaning treatments to prepare the area. Authors Mahdi Kadkhoazadeh, DDS, MSc, and Ali Azadi, DDS, state, "It cannot be denied that the assessment of long-term outcomes of the management protocols of peri-implantitis is crucial for clinical decision-making to reduce implant failure and the consequent patient morbidity. Therefore, an investigation of the effect of xenogenic materials on the regeneration and reconstruction of the peri-implant tissues damaged due to peri-implantitis seems necessary."
A 64-year-old woman presented for treatment for peri-implantitis around the lower molar implant site. The examination revealed bleeding on probing and extensive bone loss. The patient underwent a series of extensive, deep cleanings with a titanium brush and decontamination with tetracycline paste, H2O2, and saline. Next, a titanium mesh was placed to aid soft-tissue regeneration, followed by a xenogenic bone substitute, and, finally, the area was covered with a xenogenic collagen matrix.
The patient recovered uneventfully from the procedures, and at the 4-year follow-up, the examination showed no inflammation, bleeding on probing, or discharge. The patient also showed bone regeneration and keratinized mucosa formation, which were previously absent on initial examination. The patient was advised to undergo further treatment with an autogenous connective tissue graft to improve soft tissue height but declined.
This case report presents the successful treatment of severe peri-implantitis in a patient using xenogenic materials. Given the positive outcome, more research and future clinical trials are strongly recommended by Kadkhoazadeh and Azadi, who also conclude, "In the presented case, the mesh technique with xenogenic bone substitute and collagen matrix effectively manages a severe peri-implantitis case. The 4-year follow-up of this specific case shows long-term stability and satisfactory clinical outcomes of this method in treating peri-implantitis while diminishing the need for a bone donor site."
- Full text of the article, "Management of a Severe Peri-implantitis Case Using Titanium Mesh Technique with Xenogenic Bone Substitute and Collagen Matrix: A 4-Year Follow-up," Journal of Oral Implantology, Vol. 51, No. 5, 2025, is available at http://www.joionline.org
About Journal of Oral Implantology
The Journal of Oral Implantology is the official publication of the American Academy of
Implant Dentistry and the American Academy of Implant Prosthodontics. It provides valuable
information to general dentists, oral surgeons, prosthodontists, periodontists, scientists, clinicians, laboratory owners and technicians, manufacturers, and educators. JOI distinguishes
Itself as the world's first and oldest journal devoted exclusively to implant dentistry. For more information about the journal or society, please visit: http://www.joionline.org
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SOURCE Journal of Oral Implantology
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