New Theory Sheds Light on How the Environment Influences Human Health
Researchers at Mount Sinai have proposed a groundbreaking new way to study the interaction between complex biological systems in the body and the environment. Their theory suggests the existence of "biodynamic interfaces," an intermediate entity between the two realms, as opposed to conventional approaches that analyze individual aspects of the interaction between the environment and humans in isolation, according to a paper published in BioEssays in October.
NEW YORK, Oct. 21, 2020 /PRNewswire-PRWeb/ -- Researchers at Mount Sinai have proposed a groundbreaking new way to study the interaction between complex biological systems in the body and the environment. Their theory suggests the existence of "biodynamic interfaces," an intermediate entity between the two realms, as opposed to conventional approaches that analyze individual aspects of the interaction between the environment and humans in isolation, according to a paper published in BioEssays in October.
The environment impacts human health in profound ways, yet few theories define the form of the relationship between human physiology and the environment. The Mount Sinai scientists believe that such complex systems cannot interact directly, but rather that their interaction requires the formation of an intermediary "interface." The scientists believe that this theory will lead to the establishment of a new field, "environmental biodynamics," that will advance the way the environment and human health are studied.
The basis of their theory arose when they compared the time period when autistic children were exposed to toxins to how the children's brains functioned afterward. At the same time, they found distinct patterns in the intake and metabolism of essential elements and toxins, which were dependent not only on the timing and magnitude of the environmental exposure but also on what was happening within the biological systems of the child's body.
"These rhythms were driven by the properties of both the biological and environmental systems, but exhibited properties independent of either system," said Manish Arora, PhD, the Edith J. Baerwald Professor and Vice Chair of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai. "They supported the existence of an interface mediating the interaction of biological and environmental systems. The interface itself, which applies constraints and passes information between interacting systems, must be the subject of inquiry because without refocusing the attention on biodynamic interfaces, how the environment impacts health cannot be discerned."
The study of the interface will allow scientists to better understand how complex systems like the environment and human physiology affect each other. Current methods using plain analysis are incomplete, the scientists say.
"The standard course of inquiry measures some aspect of the environment like lead in the water, and we'd link this to some aspect in human development like IQ," said Paul Curtin, PhD, Assistant Professor of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai, an author on the paper. "We've learned a lot from environmental health using this approach, but it has its limits."
This interface also considers social, behavioral, and cultural dynamics to be a particularly fruitful avenue of research. This new theory would allow scientists to assess the interface between income and other processes, including health outcomes using dynamical systems methods. It would also define how human activities could negatively influence the environment and negatively influence their own health outcomes and further environmental impacts over time.
Dr. Arora's work was funded by a prestigious Revolutionizing Innovative, Visionary Environmental Health (RIVER) Award from the National Institute of Environmental Health Sciences, totaling $8 million over eight years to complete research on the biodynamic interface. Alessandro Giuliani, PhD, Professor of Environmental Health at the University of Rome, has made a significant contribute to the development of the theory.
"Arora, Giuliani, and Curtin's conjecture is potentially a major breakthrough, as knowing the factors that influence biological time may be the key to understanding why people age or mature at different rates, and how our early life experiences can influence our health as adults," said Robert O. Wright, MD, MPH, Ethel H. Wise Professor and Chair of Environmental Medicine and Public Health and Director of the Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality care—from prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty and our physicians in the top 1% of all physicians nationally by U.S. News & World Report.
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SOURCE Mount Sinai Health System
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